4z9g
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395 in a hexagonal setting with translational non-crystallographic symmetry== | |
| - | + | <StructureSection load='4z9g' size='340' side='right' caption='[[4z9g]], [[Resolution|resolution]] 3.18Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4z9g]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z9G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z9G FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1Q5:3,6-DIMETHYL-N-(PENTAN-3-YL)-2-(2,4,6-TRIMETHYLPHENOXY)PYRIDIN-4-AMINE'>1Q5</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4k5y|4k5y]]</td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z9g OCA], [http://pdbe.org/4z9g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z9g RCSB], [http://www.ebi.ac.uk/pdbsum/4z9g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z9g ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CRFR1_HUMAN CRFR1_HUMAN]] Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.<ref>PMID:18801728</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Lysozyme]] | ||
| + | [[Category: Bortolato, A]] | ||
| + | [[Category: Cheng, R K.Y]] | ||
| + | [[Category: Dore, A S]] | ||
[[Category: Hollenstein, K]] | [[Category: Hollenstein, K]] | ||
| - | [[Category: | + | [[Category: Marshall, F H]] |
| - | [[Category: | + | [[Category: Read, R J]] |
| - | [[Category: | + | [[Category: Family b]] |
| - | [[Category: | + | [[Category: G-protein]] |
| - | [[Category: | + | [[Category: Gpcr]] |
| + | [[Category: Hexagonal]] | ||
| + | [[Category: Membrane]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Receptor]] | ||
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Tnc]] | ||
Revision as of 10:13, 13 July 2016
Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395 in a hexagonal setting with translational non-crystallographic symmetry
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Categories: Lysozyme | Bortolato, A | Cheng, R K.Y | Dore, A S | Hollenstein, K | Marshall, F H | Read, R J | Family b | G-protein | Gpcr | Hexagonal | Membrane | Membrane protein | Receptor | Signaling protein | Tnc
