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1a02

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[[Image:1a02.gif|left|200px]]
[[Image:1a02.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1a02 |SIZE=350|CAPTION= <scene name='initialview01'>1a02</scene>, resolution 2.700&Aring;
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The line below this paragraph, containing "STRUCTURE_1a02", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= NFAT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1a02| PDB=1a02 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a02 OCA], [http://www.ebi.ac.uk/pdbsum/1a02 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a02 RCSB]</span>
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}}
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'''STRUCTURE OF THE DNA BINDING DOMAINS OF NFAT, FOS AND JUN BOUND TO DNA'''
'''STRUCTURE OF THE DNA BINDING DOMAINS OF NFAT, FOS AND JUN BOUND TO DNA'''
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[[Category: Hogan, P G.]]
[[Category: Hogan, P G.]]
[[Category: Rao, A.]]
[[Category: Rao, A.]]
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[[Category: ap-1]]
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[[Category: Ap-1]]
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[[Category: combinatorial gene regulation]]
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[[Category: Combinatorial gene regulation]]
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[[Category: fos-jun]]
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[[Category: Fos-jun]]
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[[Category: nf-at]]
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[[Category: Nf-at]]
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[[Category: nfat]]
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[[Category: Nfat]]
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[[Category: quaternary protein-dna complex]]
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[[Category: Quaternary protein-dna complex]]
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[[Category: transcription factor]]
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[[Category: Transcription factor]]
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[[Category: transcription synergy]]
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[[Category: Transcription synergy]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:36:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:30:13 2008''
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Revision as of 06:36, 2 May 2008

Image:1a02.gif

Template:STRUCTURE 1a02

STRUCTURE OF THE DNA BINDING DOMAINS OF NFAT, FOS AND JUN BOUND TO DNA


Overview

The nuclear factor of activated T cells (NFAT) and the AP-1 heterodimer, Fos-Jun, cooperatively bind a composite DNA site and synergistically activate the expression of many immune-response genes. A 2.7-A-resolution crystal structure of the DNA-binding domains of NFAT, Fos and Jun, in a quaternary complex with a DNA fragment containing the distal antigen-receptor response element from the interleukin-2 gene promoter, shows an extended interface between NFAT and AP-1, facilitated by the bending of Fos and DNA. The tight association of the three proteins on DNA creates a continuous groove for the recognition of 15 base pairs.

About this Structure

1A02 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA., Chen L, Glover JN, Hogan PG, Rao A, Harrison SC, Nature. 1998 Mar 5;392(6671):42-8. PMID:9510247 Page seeded by OCA on Fri May 2 09:36:22 2008

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