5e8i
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | ''' | + | ==Crystal structure of the DNA binding domain of human transcription factor FLI1 in complex with a 10-mer DNA ACCGGAAGTG== |
| - | + | <StructureSection load='5e8i' size='340' side='right' caption='[[5e8i]], [[Resolution|resolution]] 3.45Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5e8i]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E8I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E8I FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5e8g|5e8g]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e8i OCA], [http://pdbe.org/5e8i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e8i RCSB], [http://www.ebi.ac.uk/pdbsum/5e8i PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[ | + | == Disease == |
| + | [[http://www.uniprot.org/uniprot/FLI1_HUMAN FLI1_HUMAN]] Defects in FLI1 are a cause of Ewing sarcoma (ES) [MIM:[http://omim.org/entry/612219 612219]]. A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=A chromosomal aberration involving FLI1 is found in patients with Erwing sarcoma. Translocation t(11;22)(q24;q12) with EWSR1. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FLI1_HUMAN FLI1_HUMAN]] Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Hou, C]] | [[Category: Hou, C]] | ||
| + | [[Category: Tsodikov, O V]] | ||
| + | [[Category: Dna binding]] | ||
| + | [[Category: Dna binding protein-dna complex]] | ||
| + | [[Category: Ets family]] | ||
| + | [[Category: Ewing sarcoma]] | ||
| + | [[Category: Transcription]] | ||
| + | [[Category: Winged helix]] | ||
Revision as of 13:49, 9 December 2015
Crystal structure of the DNA binding domain of human transcription factor FLI1 in complex with a 10-mer DNA ACCGGAAGTG
| |||||||||||
