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5ec2
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==KcsA with V76ester+G77dA mutations== | |
| - | + | <StructureSection load='5ec2' size='340' side='right' caption='[[5ec2]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ec2]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EC2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EC2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | |
| - | [[ | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=LHV:(2S)-2-HYDROXY-3-METHYLBUTANOIC+ACID'>LHV</scene></td></tr> |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ebl|5ebl]], [[5ebm|5ebm]], [[5ebw|5ebw]], [[5ec1|5ec1]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ec2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ec2 OCA], [http://pdbe.org/5ec2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ec2 RCSB], [http://www.ebi.ac.uk/pdbsum/5ec2 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Matulef, K]] | [[Category: Matulef, K]] | ||
| + | [[Category: Valiyaveetil, F I]] | ||
| + | [[Category: Alpha-helical]] | ||
| + | [[Category: Channel]] | ||
| + | [[Category: Fab]] | ||
| + | [[Category: Membrane protein]] | ||
Revision as of 18:43, 12 May 2016
KcsA with V76ester+G77dA mutations
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