5ecy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "5ecy" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5ecy is ON HOLD
+
==Structure of the Shigella flexneri VapC mutant D98N crystal form 2==
-
 
+
<StructureSection load='5ecy' size='340' side='right' caption='[[5ecy]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
Authors: Xu, K., Dedic, E., Brodersen, D.E.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5ecy]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ECY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ECY FirstGlance]. <br>
-
Description: Structure of the Shigella flexneri VapC mutant D98N crystal form 2
+
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ecd|5ecd]]</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ecy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ecy OCA], [http://pdbe.org/5ecy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ecy RCSB], [http://www.ebi.ac.uk/pdbsum/5ecy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ecy ProSAT]</span></td></tr>
-
[[Category: Brodersen, D.E]]
+
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/VAPC_SHIFL VAPC_SHIFL]] Toxic component of a toxin-antitoxin (TA) module. A tRNA-(fMet) endonuclease, it cleaves both charged and uncharged tRNA-(fMet) between positions 38 and 39 at the anticodon stem-loop boundary. Does not cleave tRNA(Met), tRNA(Arg2), tRNA(His), tRNA(Leu), tRNA(Phe) tRNA(Thr1), tRNA(Tyr) or tRNA(Val). Overexpression in E.coli inhibits translation, leads to loss of cell growth and degradation of tRNA(fMet); these effects are neutralized by expression of cognate antitoxin VapB. The VapB/VapC complex probably regulates transcription of its own promoter.<ref>PMID:19400780</ref> <ref>PMID:21502523</ref> Ectopic overexpression in E.coli induces the YoeB toxin, but this is not the cause of VapC toxicity.<ref>PMID:19400780</ref> <ref>PMID:21502523</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Brodersen, D E]]
 +
[[Category: Dedic, E]]
[[Category: Xu, K]]
[[Category: Xu, K]]
-
[[Category: Dedic, E]]
+
[[Category: Hydrolase]]
 +
[[Category: Pin-domain]]
 +
[[Category: Toxin]]

Revision as of 00:56, 20 October 2016

Structure of the Shigella flexneri VapC mutant D98N crystal form 2

5ecy, resolution 2.00Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5ecy"
Personal tools