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5ecy

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m (Protected "5ecy" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5ecy is ON HOLD
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==Structure of the Shigella flexneri VapC mutant D98N crystal form 2==
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<StructureSection load='5ecy' size='340' side='right' caption='[[5ecy]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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Authors: Xu, K., Dedic, E., Brodersen, D.E.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ecy]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ECY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ECY FirstGlance]. <br>
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Description: Structure of the Shigella flexneri VapC mutant D98N crystal form 2
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ecd|5ecd]]</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ecy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ecy OCA], [http://pdbe.org/5ecy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ecy RCSB], [http://www.ebi.ac.uk/pdbsum/5ecy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ecy ProSAT]</span></td></tr>
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[[Category: Brodersen, D.E]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/VAPC_SHIFL VAPC_SHIFL]] Toxic component of a toxin-antitoxin (TA) module. A tRNA-(fMet) endonuclease, it cleaves both charged and uncharged tRNA-(fMet) between positions 38 and 39 at the anticodon stem-loop boundary. Does not cleave tRNA(Met), tRNA(Arg2), tRNA(His), tRNA(Leu), tRNA(Phe) tRNA(Thr1), tRNA(Tyr) or tRNA(Val). Overexpression in E.coli inhibits translation, leads to loss of cell growth and degradation of tRNA(fMet); these effects are neutralized by expression of cognate antitoxin VapB. The VapB/VapC complex probably regulates transcription of its own promoter.<ref>PMID:19400780</ref> <ref>PMID:21502523</ref> Ectopic overexpression in E.coli induces the YoeB toxin, but this is not the cause of VapC toxicity.<ref>PMID:19400780</ref> <ref>PMID:21502523</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Brodersen, D E]]
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[[Category: Dedic, E]]
[[Category: Xu, K]]
[[Category: Xu, K]]
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[[Category: Dedic, E]]
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[[Category: Hydrolase]]
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[[Category: Pin-domain]]
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[[Category: Toxin]]

Revision as of 00:56, 20 October 2016

Structure of the Shigella flexneri VapC mutant D98N crystal form 2

5ecy, resolution 2.00Å

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