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1a1n

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[[Image:1a1n.gif|left|200px]]
[[Image:1a1n.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1a1n", creates the "Structure Box" on the page.
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|GENE= T7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_1a1n| PDB=1a1n | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a1n OCA], [http://www.ebi.ac.uk/pdbsum/1a1n PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a1n RCSB]</span>
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'''MHC CLASS I MOLECULE B*3501 COMPLEXED WITH PEPTIDE VPLRPMTY FROM THE NEF PROTEIN (75-82) OF HIV1'''
'''MHC CLASS I MOLECULE B*3501 COMPLEXED WITH PEPTIDE VPLRPMTY FROM THE NEF PROTEIN (75-82) OF HIV1'''
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[[Category: Smith, K J.]]
[[Category: Smith, K J.]]
[[Category: Stuart, D I.]]
[[Category: Stuart, D I.]]
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[[Category: complex (antigen/peptide)]]
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[[Category: Hiv]]
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[[Category: hiv]]
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[[Category: Hla]]
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[[Category: hla]]
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[[Category: Hla-b3501]]
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[[Category: hla-b3501]]
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[[Category: Major histocompatibility antigen]]
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[[Category: major histocompatibility antigen]]
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[[Category: Mhc]]
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[[Category: mhc]]
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[[Category: Nef]]
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[[Category: nef]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:40:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:31:08 2008''
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Revision as of 06:40, 2 May 2008

Image:1a1n.gif

Template:STRUCTURE 1a1n

MHC CLASS I MOLECULE B*3501 COMPLEXED WITH PEPTIDE VPLRPMTY FROM THE NEF PROTEIN (75-82) OF HIV1


Overview

The crystal structure of the human major histocompatibility complex class I B allele HLA B*3501 complexed with the 8-mer peptide epitope HIV1 Nef 75-82 (VPLRPMTY) has been determined at 2.0 angstrom resolution. Comparison with the crystal structure of the closely related allele HLA B*5301 reveals the structural basis for the tyrosine specificity of the B*3501 F pocket. The structure also reveals a novel conformation of the 8-mer peptide within the binding groove. The positions of the peptide N and C termini are nonstandard, but the classic pattern of hydrogen bonding to nonpolymorphic MHC class I residues is maintained, at the N terminus by addition of a water molecule, and at the C terminus by a substantial shift in the alpha 2 helix.

About this Structure

1A1N is a Protein complex structure of sequences from Homo sapiens and Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

An altered position of the alpha 2 helix of MHC class I is revealed by the crystal structure of HLA-B*3501., Smith KJ, Reid SW, Stuart DI, McMichael AJ, Jones EY, Bell JI, Immunity. 1996 Mar;4(3):203-13. PMID:8624811 Page seeded by OCA on Fri May 2 09:40:24 2008

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