5eet
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of murine neuroglobin at ambient pressure== | |
| - | + | <StructureSection load='5eet' size='340' side='right' caption='[[5eet]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5eet]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EET OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EET FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eet OCA], [http://pdbe.org/5eet PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eet RCSB], [http://www.ebi.ac.uk/pdbsum/5eet PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eet ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NGB_MOUSE NGB_MOUSE]] Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.<ref>PMID:11473111</ref> <ref>PMID:11473128</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Girard, E]] | ||
[[Category: Vallone, B]] | [[Category: Vallone, B]] | ||
| - | [[Category: | + | [[Category: H, N Colloc]] |
| + | [[Category: Globin]] | ||
| + | [[Category: Oxygen storage-transporter]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 00:56, 20 October 2016
Crystal structure of murine neuroglobin at ambient pressure
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