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5enj
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with compound-14 N11530 (SGC - Diamond I04-1 fragment screening)== | |
| - | + | <StructureSection load='5enj' size='340' side='right' caption='[[5enj]], [[Resolution|resolution]] 1.63Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5enj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ENJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ENJ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5Q9:~{N}-[[2,6-BIS(CHLORANYL)PHENYL]METHYL]-~{N}-METHYL-ETHANAMIDE'>5Q9</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5enj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5enj OCA], [http://pdbe.org/5enj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5enj RCSB], [http://www.ebi.ac.uk/pdbsum/5enj PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PHIP_HUMAN PHIP_HUMAN]] Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.<ref>PMID:12242307</ref> <ref>PMID:21834987</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Bradley, A]] | ||
| + | [[Category: Brennan, P]] | ||
[[Category: Burgess-Brown, N]] | [[Category: Burgess-Brown, N]] | ||
| - | [[Category: Krojer, T]] | ||
| - | [[Category: Bountra, C]] | ||
[[Category: Collins, P]] | [[Category: Collins, P]] | ||
[[Category: Cox, O]] | [[Category: Cox, O]] | ||
| - | [[Category: | + | [[Category: Delft, F von]] |
| + | [[Category: Edwards, A]] | ||
| + | [[Category: Krojer, T]] | ||
| + | [[Category: Structural genomic]] | ||
[[Category: Szykowska, A]] | [[Category: Szykowska, A]] | ||
| - | [[Category: Von Delft, F]] | ||
[[Category: Talon, R]] | [[Category: Talon, R]] | ||
| - | [[Category: | + | [[Category: Bromodomain]] |
| - | [[Category: | + | [[Category: Crystallographic fragment screen]] |
| - | [[Category: | + | [[Category: Phip]] |
| - | [[Category: | + | [[Category: Sgc]] |
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 12:03, 13 May 2016
Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with compound-14 N11530 (SGC - Diamond I04-1 fragment screening)
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