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1a66

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[[Image:1a66.jpg|left|200px]]
[[Image:1a66.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1a66 |SIZE=350|CAPTION= <scene name='initialview01'>1a66</scene>
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The line below this paragraph, containing "STRUCTURE_1a66", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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|GENE= NFATC1(416-591) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1a66| PDB=1a66 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a66 OCA], [http://www.ebi.ac.uk/pdbsum/1a66 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a66 RCSB]</span>
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}}
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'''SOLUTION NMR STRUCTURE OF THE CORE NFATC1/DNA COMPLEX, 18 STRUCTURES'''
'''SOLUTION NMR STRUCTURE OF THE CORE NFATC1/DNA COMPLEX, 18 STRUCTURES'''
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[[Category: Wagner, G.]]
[[Category: Wagner, G.]]
[[Category: Zhou, P.]]
[[Category: Zhou, P.]]
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[[Category: arre2]]
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[[Category: Arre2]]
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[[Category: binary]]
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[[Category: Binary]]
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[[Category: binary complex]]
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[[Category: Binary complex]]
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[[Category: complex]]
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[[Category: Complex]]
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[[Category: enhanceosome]]
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[[Category: Enhanceosome]]
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[[Category: il-2]]
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[[Category: Il-2]]
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[[Category: nfat]]
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[[Category: Nfat]]
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[[Category: nfat/dna]]
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[[Category: Nfat/dna]]
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[[Category: nfat2]]
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[[Category: Nfat2]]
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[[Category: nfatc]]
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[[Category: Nfatc]]
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[[Category: nfatc1]]
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[[Category: Nfatc1]]
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[[Category: nfatc1/dna]]
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[[Category: Nfatc1/dna]]
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[[Category: nmr]]
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[[Category: Nmr]]
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[[Category: rel]]
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[[Category: Rel]]
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[[Category: transcription factor]]
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[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:52:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:34:07 2008''
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Revision as of 06:52, 2 May 2008

Image:1a66.jpg

Template:STRUCTURE 1a66

SOLUTION NMR STRUCTURE OF THE CORE NFATC1/DNA COMPLEX, 18 STRUCTURES


Overview

The nuclear factor of the activated T cell (NFAT) family of transcription factors regulates cytokine gene expression by binding to the promoter/enhancer regions of antigen-responsive genes, usually in cooperation with heterologous DNA-binding partners. Here we report the solution structure of the binary complex formed between the core DNA-binding domain of human NFATC1 and the ARRE2 DNA site from the interleukin-2 promoter. The structure reveals that DNA binding induces the folding of key structural elements that are required for both sequence-specific recognition and the establishment of cooperative protein-protein contacts. The orientation of the NFAT DNA-binding domain observed in the binary NFATC1-DBD*/ DNA complex is distinct from that seen in the ternary NFATC2/AP-1/DNA complex, suggesting that the domain reorients upon formation of a cooperative transcriptional complex.

About this Structure

1A66 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Solution structure of the core NFATC1/DNA complex., Zhou P, Sun LJ, Dotsch V, Wagner G, Verdine GL, Cell. 1998 Mar 6;92(5):687-96. PMID:9506523 Page seeded by OCA on Fri May 2 09:52:13 2008

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