1a6i

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[[Image:1a6i.gif|left|200px]]
[[Image:1a6i.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1a6i", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=TNE:Empty+Tetracycline+Binding+Tunnel'>TNE</scene>
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{{STRUCTURE_1a6i| PDB=1a6i | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a6i OCA], [http://www.ebi.ac.uk/pdbsum/1a6i PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a6i RCSB]</span>
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'''TET REPRESSOR, CLASS D VARIANT'''
'''TET REPRESSOR, CLASS D VARIANT'''
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[[Category: Saenger, W.]]
[[Category: Saenger, W.]]
[[Category: Schnappinger, D.]]
[[Category: Schnappinger, D.]]
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[[Category: dna-binding]]
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[[Category: Dna-binding]]
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[[Category: repressor]]
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[[Category: Repressor]]
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[[Category: transcription regulation]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:53:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:34:22 2008''
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Revision as of 06:53, 2 May 2008

Image:1a6i.gif

Template:STRUCTURE 1a6i

TET REPRESSOR, CLASS D VARIANT


Overview

The X-ray crystal structure analysis of inducer-free Tet repressor, TetR, at 2.4 A resolution identifies one of two openings of the tunnel-like binding site as the entrance for the inducer tetracycline-Mg2+, [Mg Tc]+. Recognition and binding of the inducer unleashes conformational changes leading to the induced state of TetR. In the first step, the C-terminal turn of alpha-helix 6 unwinds, thereby altering the orientation of alpha-helix 4. This different orientation of alpha-helix 4 is stabilized by a series of hydrogen bonds mediated through a chain of eight water molecules. The alpha-helix 4 connects the DNA-binding domain (alpha-helices 1 to 3) to the rigid TetR core, and thus regulates gene expression through its respective orientations.

About this Structure

1A6I is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Conformational changes of the Tet repressor induced by tetracycline trapping., Orth P, Cordes F, Schnappinger D, Hillen W, Saenger W, Hinrichs W, J Mol Biol. 1998 Jun 5;279(2):439-47. PMID:9642048 Page seeded by OCA on Fri May 2 09:53:22 2008

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