5eut
From Proteopedia
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| - | ''' | + | ==Crystal structure of phosphatidyl inositol 4-kinase II alpha in the apo state== |
| - | + | <StructureSection load='5eut' size='340' side='right' caption='[[5eut]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5eut]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EUT FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eut OCA], [http://pdbe.org/5eut PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eut RCSB], [http://www.ebi.ac.uk/pdbsum/5eut PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [[http://www.uniprot.org/uniprot/P4K2A_HUMAN P4K2A_HUMAN]] Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells (By similarity). This lipid kinase is the major phosphatidylinositol 4-phosphate (PI4P) producer in the Golgi apparatus, it generates more than 50% of this molecule which is essential for the identity of the organelle, protein sorting and membrane trafficking. | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Baumlova, A]] | [[Category: Baumlova, A]] | ||
| + | [[Category: Boura, E]] | ||
| + | [[Category: Kinase]] | ||
| + | [[Category: Lipid]] | ||
| + | [[Category: Phosphatidylinositol]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 12:50, 23 December 2015
Crystal structure of phosphatidyl inositol 4-kinase II alpha in the apo state
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