1a77

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[[Image:1a77.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1a77", creates the "Structure Box" on the page.
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a77 OCA], [http://www.ebi.ac.uk/pdbsum/1a77 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a77 RCSB]</span>
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'''FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII'''
'''FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII'''
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[[Category: Kim, H.]]
[[Category: Kim, H.]]
[[Category: 5'-3' exo/endo nuclease]]
[[Category: 5'-3' exo/endo nuclease]]
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[[Category: dna repair]]
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[[Category: Dna repair]]
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[[Category: dna replication]]
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[[Category: Dna replication]]
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[[Category: rad27]]
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[[Category: Rad27]]
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[[Category: rth]]
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[[Category: Rth]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:55:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:34:45 2008''
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Revision as of 06:55, 2 May 2008

Image:1a77.jpg

Template:STRUCTURE 1a77

FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII


Overview

Flap endonuclease-1 (FEN-1), a structure specific nuclease, is an essential enzyme for eukaryotic DNA replication and repair. The crystal structure of FEN-1 from Methanococcus jannaschii, determined at 2.0 A resolution, reveals an active site with two metal ions residing on top of a deep cleft where several conserved acidic residues are clustered. Near the active site, a long flexible loop comprised of many basic and aromatic residues forms a hole large enough to accommodate the DNA substrate. Deletion mutations in this loop significantly decreased the nuclease activity and specificity of FEN-1, suggesting that the loop is critical for recognition and cleavage of the junction between single and double-stranded regions of flap DNA.

About this Structure

1A77 is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

The crystal structure of flap endonuclease-1 from Methanococcus jannaschii., Hwang KY, Baek K, Kim HY, Cho Y, Nat Struct Biol. 1998 Aug;5(8):707-13. PMID:9699635 Page seeded by OCA on Fri May 2 09:55:11 2008

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