5flu
From Proteopedia
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| - | ''' | + | ==Structure of a Chaperone-Usher pilus reveals the molecular basis of rod uncoilin== |
| + | <StructureSection load='5flu' size='340' side='right' caption='[[5flu]], [[Resolution|resolution]] 3.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5flu]] is a 13 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FLU FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5flu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5flu OCA], [http://pdbe.org/5flu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5flu RCSB], [http://www.ebi.ac.uk/pdbsum/5flu PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PAPA_ECOLX PAPA_ECOLX]] Polymerizes to form the thick (6.8 nm in diameter) rod of the pilus (also called fimbria). The rod is a right-handed helical cylinder with 3.28 PapA subunits per turn. Pili are polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, and enable bacteria to colonize the epithelium of specific host organs. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Types 1 and P pili are prototypical bacterial cell-surface appendages playing essential roles in mediating adhesion of bacteria to the urinary tract. These pili, assembled by the chaperone-usher pathway, are polymers of pilus subunits assembling into two parts: a thin, short tip fibrillum at the top, mounted on a long pilus rod. The rod adopts a helical quaternary structure and is thought to play essential roles: its formation may drive pilus extrusion by preventing backsliding of the nascent growing pilus within the secretion pore; the rod also has striking spring-like properties, being able to uncoil and recoil depending on the intensity of shear forces generated by urine flow. Here, we present an atomic model of the P pilus generated from a 3.8 A resolution cryo-electron microscopy reconstruction. This structure provides the molecular basis for the rod's remarkable mechanical properties and illuminates its role in pilus secretion. | ||
| - | + | Structure of a Chaperone-Usher Pilus Reveals the Molecular Basis of Rod Uncoiling.,Hospenthal MK, Redzej A, Dodson K, Ukleja M, Frenz B, Rodrigues C, Hultgren SJ, DiMaio F, Egelman EH, Waksman G Cell. 2015 Dec 22. pii: S0092-8674(15)01568-8. doi: 10.1016/j.cell.2015.11.049. PMID:26724865<ref>PMID:26724865</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 5flu" style="background-color:#fffaf0;"></div> | |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: Egelman, E | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: DiMaio, F]] | ||
| + | [[Category: Dodson, K]] | ||
| + | [[Category: Egelman, E H]] | ||
| + | [[Category: Frenz, B]] | ||
| + | [[Category: Hospenthal, M K]] | ||
| + | [[Category: Hultgren, S J]] | ||
[[Category: Redzej, A]] | [[Category: Redzej, A]] | ||
| - | [[Category: Hultgren, S.J]] | ||
| - | [[Category: Frenz, B]] | ||
[[Category: Ukleja, M]] | [[Category: Ukleja, M]] | ||
| - | [[Category: | + | [[Category: Waksman, G]] |
| - | [[Category: | + | [[Category: Helical polymer]] |
| + | [[Category: Strand donation]] | ||
| + | [[Category: Structural protein]] | ||
Revision as of 20:03, 13 January 2016
Structure of a Chaperone-Usher pilus reveals the molecular basis of rod uncoilin
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