5fn1
From Proteopedia
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| - | ''' | + | ==Electron cryo-microscopy of filamentous flexible virus PepMV (Pepino Mosaic Virus)== |
| + | <StructureSection load='5fn1' size='340' side='right' caption='[[5fn1]], [[Resolution|resolution]] 3.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5fn1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pepino_mosaic_virus Pepino mosaic virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FN1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FN1 FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fn1 OCA], [http://pdbe.org/5fn1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fn1 RCSB], [http://www.ebi.ac.uk/pdbsum/5fn1 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Flexible filamentous viruses include economically important plant pathogens. Their viral particles contain several hundred copies of a helically arrayed coat protein (CP) protecting a (+)ssRNA. We describe here a structure at 3.9 A resolution, from electron cryomicroscopy, of Pepino mosaic virus (PepMV), a representative of the genus Potexvirus (family Alphaflexiviridae). Our results allow modeling of the CP and its interactions with viral RNA. The overall fold of PepMV CP resembles that of nucleoproteins (NPs) from the genus Phlebovirus (family Bunyaviridae), a group of enveloped (-)ssRNA viruses. The main difference between potexvirus CP and phlebovirus NP is in their C-terminal extensions, which appear to determine the characteristics of the distinct multimeric assemblies- a flexuous, helical rod or a loose ribonucleoprotein (RNP). The homology suggests gene transfer between eukaryotic (+) and (-)ssRNA viruses. | ||
| - | The | + | The near-atomic cryoEM structure of a flexible filamentous plant virus shows homology of its coat protein with nucleoproteins of animal viruses.,Agirrezabala X, Mendez-Lopez E, Lasso G, Sanchez-Pina MA, Aranda M, Valle M Elife. 2015 Dec 16;4. pii: e11795. doi: 10.7554/eLife.11795. PMID:26673077<ref>PMID:26673077</ref> |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 5fn1" style="background-color:#fffaf0;"></div> | |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Pepino mosaic virus]] | ||
| + | [[Category: Agirrezabala, X]] | ||
| + | [[Category: Aranda, M A]] | ||
[[Category: Lasso, G]] | [[Category: Lasso, G]] | ||
| - | [[Category: Aranda, M.A]] | ||
[[Category: Mendez-Lopez, E]] | [[Category: Mendez-Lopez, E]] | ||
| - | [[Category: Sanchez-Pina, M | + | [[Category: Sanchez-Pina, M A]] |
| - | [[Category: | + | [[Category: Valle, M]] |
| + | [[Category: Filamentous plant virus]] | ||
| + | [[Category: Helical symmetry]] | ||
| + | [[Category: Pepmv]] | ||
| + | [[Category: Potexvirus]] | ||
| + | [[Category: Virus]] | ||
Revision as of 19:26, 30 December 2015
Electron cryo-microscopy of filamentous flexible virus PepMV (Pepino Mosaic Virus)
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