1aa6

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[[Image:1aa6.gif|left|200px]]
[[Image:1aa6.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1aa6 |SIZE=350|CAPTION= <scene name='initialview01'>1aa6</scene>, resolution 2.3&Aring;
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The line below this paragraph, containing "STRUCTURE_1aa6", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=4MO:The+Mo+Atom+Is+Coordinated+To+The+Se+Atom+Of+Sec+140+And+...'>4MO</scene> and <scene name='pdbsite=FS4:The+Fe+S+Cluster+Is+Coordinated+To+The+S+Atoms+Of+CYS+8,+...'>FS4</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=4MO:MOLYBDENUM(IV)+ION'>4MO</scene>, <scene name='pdbligand=CSE:SELENOCYSTEINE'>CSE</scene>, <scene name='pdbligand=MGD:2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE+GUANOSINE+DINUCLEOTIDE'>MGD</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Formate_dehydrogenase Formate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.2 1.2.1.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= FDHF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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-->
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|DOMAIN=
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{{STRUCTURE_1aa6| PDB=1aa6 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aa6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aa6 OCA], [http://www.ebi.ac.uk/pdbsum/1aa6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1aa6 RCSB]</span>
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}}
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'''REDUCED FORM OF FORMATE DEHYDROGENASE H FROM E. COLI'''
'''REDUCED FORM OF FORMATE DEHYDROGENASE H FROM E. COLI'''
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[[Category: Boyington, J C.]]
[[Category: Boyington, J C.]]
[[Category: Sun, P D.]]
[[Category: Sun, P D.]]
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[[Category: anaerobic]]
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[[Category: Anaerobic]]
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[[Category: dehydrogenase]]
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[[Category: Dehydrogenase]]
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[[Category: fe4s4]]
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[[Category: Fe4s4]]
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[[Category: formate]]
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[[Category: Formate]]
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[[Category: iron sulfur cluster]]
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[[Category: Iron sulfur cluster]]
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[[Category: mgd]]
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[[Category: Mgd]]
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[[Category: molybdenum]]
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[[Category: Molybdenum]]
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[[Category: molybdopterin]]
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[[Category: Molybdopterin]]
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[[Category: molybdopterin guanine dinucleotide]]
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[[Category: Molybdopterin guanine dinucleotide]]
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[[Category: mpt]]
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[[Category: Mpt]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: secy]]
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[[Category: Secy]]
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[[Category: selenium]]
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[[Category: Selenium]]
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[[Category: selenocysteine]]
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[[Category: Selenocysteine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:02:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:36:28 2008''
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Revision as of 07:02, 2 May 2008

Image:1aa6.gif

Template:STRUCTURE 1aa6

REDUCED FORM OF FORMATE DEHYDROGENASE H FROM E. COLI


Overview

Formate dehydrogenase H from Escherichia coli contains selenocysteine (SeCys), molybdenum, two molybdopterin guanine dinucleotide (MGD) cofactors, and an Fe4S4 cluster at the active site and catalyzes the two-electron oxidation of formate to carbon dioxide. The crystal structures of the oxidized [Mo(VI), Fe4S4(ox)] form of formate dehydrogenase H (with and without bound inhibitor) and the reduced [Mo(IV), Fe4S4(red)] form have been determined, revealing a four-domain alphabeta structure with the molybdenum directly coordinated to selenium and both MGD cofactors. These structures suggest a reaction mechanism that directly involves SeCys140 and His141 in proton abstraction and the molybdenum, molybdopterin, Lys44, and the Fe4S4 cluster in electron transfer.

About this Structure

1AA6 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of formate dehydrogenase H: catalysis involving Mo, molybdopterin, selenocysteine, and an Fe4S4 cluster., Boyington JC, Gladyshev VN, Khangulov SV, Stadtman TC, Sun PD, Science. 1997 Feb 28;275(5304):1305-8. PMID:9036855 Page seeded by OCA on Fri May 2 10:02:26 2008

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