Adapter molecule crk

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== Function ==
== Function ==
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'''Adapter molecule crk''' (Crk) ('''C'''T10 '''R'''egulatior of '''K'''inase) or '''p38''' is a proto-oncogene which participates in the Reelin signaling cascade. Crk binds to several tyrosine-phosphorylated proteins.
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'''Adapter molecule crk''' (Crk) ('''C'''T10 '''R'''egulatior of '''K'''inase) or '''p38''' is a proto-oncogene which participates in the Reelin signaling cascade. Crk binds to several tyrosine-phosphorylated proteins.<ref>PMID:12086608</ref>
== Structural highlights ==
== Structural highlights ==
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== References ==
== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:57, 3 December 2015

Structure of mouse Crk N terminal SH3 domain (grey) complex with proline-rich peptide (green) (PDB entry 1cka)

Drag the structure with the mouse to rotate

3D structures of adpter molecule crk

1m30, 1m3a, 1m3b, 1m3c – mCrk N terminal SH3 (mutant) – mouse - NMR
2ggr – mCrk C terminal SH3 - NMR
2l3p, 2l3q, 2l3s – Crk residues 220-297 – chicken – NMR
1cka, 1ckb – mCrk N terminal SH3 + proline-rich peptide
1b07 – mCrk N terminal SH3 + SH3 peptoid inhibitor
1ju5 – hCrk SH2 + phosphopeptide + Abl SH3 - human

References

  1. ↑ Collins BM, McCoy AJ, Kent HM, Evans PR, Owen DJ. Molecular architecture and functional model of the endocytic AP2 complex. Cell. 2002 May 17;109(4):523-35. PMID:12086608

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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