1ad5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1ad5.jpg|left|200px]]
[[Image:1ad5.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1ad5 |SIZE=350|CAPTION= <scene name='initialview01'>1ad5</scene>, resolution 2.6&Aring;
+
The line below this paragraph, containing "STRUCTURE_1ad5", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= HUMAN HCK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1ad5| PDB=1ad5 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ad5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ad5 OCA], [http://www.ebi.ac.uk/pdbsum/1ad5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ad5 RCSB]</span>
+
-
}}
+
'''SRC FAMILY KINASE HCK-AMP-PNP COMPLEX'''
'''SRC FAMILY KINASE HCK-AMP-PNP COMPLEX'''
Line 29: Line 26:
[[Category: Moarefi, I.]]
[[Category: Moarefi, I.]]
[[Category: Sicheri, F.]]
[[Category: Sicheri, F.]]
-
[[Category: phosphorylation]]
+
[[Category: Phosphorylation]]
-
[[Category: sh2]]
+
[[Category: Sh2]]
-
[[Category: sh3]]
+
[[Category: Sh3]]
-
[[Category: signal transduction]]
+
[[Category: Signal transduction]]
-
[[Category: transferase]]
+
[[Category: Transferase]]
-
[[Category: tyrosine-protein kinase]]
+
[[Category: Tyrosine-protein kinase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:07:08 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:37:46 2008''
+

Revision as of 07:07, 2 May 2008

Image:1ad5.jpg

Template:STRUCTURE 1ad5

SRC FAMILY KINASE HCK-AMP-PNP COMPLEX


Overview

The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases.

About this Structure

1AD5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Src family tyrosine kinase Hck., Sicheri F, Moarefi I, Kuriyan J, Nature. 1997 Feb 13;385(6617):602-9. PMID:9024658 Page seeded by OCA on Fri May 2 10:07:08 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ad5"
Personal tools