1ad6
From Proteopedia
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'''DOMAIN A OF HUMAN RETINOBLASTOMA TUMOR SUPPRESSOR''' | '''DOMAIN A OF HUMAN RETINOBLASTOMA TUMOR SUPPRESSOR''' | ||
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[[Category: Cho, Y.]] | [[Category: Cho, Y.]] | ||
[[Category: Kim, H Y.]] | [[Category: Kim, H Y.]] | ||
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| - | [[Category: | + | [[Category: Tumor suppressor]] |
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Revision as of 07:07, 2 May 2008
DOMAIN A OF HUMAN RETINOBLASTOMA TUMOR SUPPRESSOR
Overview
The pocket region of retinoblastoma tumour suppressor (Rb) is essential for tumour suppressing activity. The Rb pocket is primarily composed of two domains, A and B. We have determined the X-ray crystal structure of domain A (residues 378-562) at 2.3 A resolution. Domain A consists of nine alpha-helices. The overall arrangement of helices in domain A is remarkably similar to the cyclin-box folds found in the crystal structures of cyclin A and TFIIB. This structure, along with domain B which is predicted to be homologous to the cyclin-box, suggests that the Rb pocket is composed of two cyclin-box fold domains. We present the structural/functional features of the Rb pocket, and the potential binding region for cellular or viral proteins within domain A.
About this Structure
1AD6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box., Kim HY, Cho Y, Nat Struct Biol. 1997 May;4(5):390-5. PMID:9145110 Page seeded by OCA on Fri May 2 10:07:12 2008
