2n9b

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'''Unreleased structure'''
 
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The entry 2n9b is ON HOLD until Paper Publication
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==Solution NMR Structure of Antiparallel Myosin-10:GCN4 Tandem Coiled-Coil==
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<StructureSection load='2n9b' size='340' side='right' caption='[[2n9b]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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Authors: Vavra, K.C., Xia, Y., Rock, R.S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2n9b]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N9B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N9B FirstGlance]. <br>
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Description: Solution NMR Structure of Antiparallel Myosin-10:GCN4 Tandem Coiled-Coil
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2lw9|2lw9]], [[2zta|2zta]]</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n9b OCA], [http://pdbe.org/2n9b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n9b RCSB], [http://www.ebi.ac.uk/pdbsum/2n9b PDBsum]</span></td></tr>
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[[Category: Rock, R.S]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/MYO10_BOVIN MYO10_BOVIN]] In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation (By similarity). Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate, which are then moved relative to actin filaments. Stimulates the formation and elongation of filopodia. Regulates cell shape, cell spreading and cell adhesion. Plays a role in formation of the podosome belt in osteoclasts.<ref>PMID:11457842</ref> <ref>PMID:15156152</ref> <ref>PMID:15705568</ref> <ref>PMID:16894163</ref> <ref>PMID:20081229</ref> <ref>PMID:20364131</ref> <ref>PMID:20392702</ref> <ref>PMID:20930142</ref> <ref>PMID:21666676</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Rock, R S]]
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[[Category: Vavra, K C]]
[[Category: Xia, Y]]
[[Category: Xia, Y]]
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[[Category: Vavra, K.C]]
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[[Category: Anti-parallel coiled-coil]]
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[[Category: Coiled-coil]]
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[[Category: Motor protein-transcription complex]]

Revision as of 22:20, 20 June 2016

Solution NMR Structure of Antiparallel Myosin-10:GCN4 Tandem Coiled-Coil

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