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Antithrombin
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
| - | '''Antithrombin''' (AT) inactivates several enzymes of the coagulation cycle. AT is relatively inactive until it binds the heparan sidechains of the microvasculature.<br /> | + | '''Antithrombin''' (AT) inactivates several enzymes of the coagulation cycle. AT is relatively inactive until it binds the heparan sidechains of the microvasculature.<ref>PMID:15311269</ref><br /> |
▪ '''α-AT''' contains 4 occupied glycosylation sites and is found in blood palsma.<br /> | ▪ '''α-AT''' contains 4 occupied glycosylation sites and is found in blood palsma.<br /> | ||
▪ '''β-AT''' contains only 3 occupied glycosylation sites.<br /> | ▪ '''β-AT''' contains only 3 occupied glycosylation sites.<br /> | ||
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}} | }} | ||
== References == | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 11:08, 3 December 2015
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3D structures of antithrombin
Updated on 03-December-2015
References
- ↑ Li W, Johnson DJ, Esmon CT, Huntington JA. Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin. Nat Struct Mol Biol. 2004 Sep;11(9):857-62. Epub 2004 Aug 15. PMID:15311269 doi:10.1038/nsmb811
