5ebd
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of EccB1 of Mycobacterium tuberculosis in spacegroup P21 (state IV)== | |
| + | <StructureSection load='5ebd' size='340' side='right' caption='[[5ebd]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5ebd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EBD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EBD FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3x3m|3x3m]], [[3x3n|3x3n]], [[5ebc|5ebc]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ebd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ebd OCA], [http://pdbe.org/5ebd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ebd RCSB], [http://www.ebi.ac.uk/pdbsum/5ebd PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ECCB1_MYCTU ECCB1_MYCTU]] Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10).<ref>PMID:16368961</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The protein EccB1, a core component of the type VII secretion system (T7SS) of Mycobacterium tuberculosis, has been identified as an ATPase and is essential for the secretion of virulence factors by the ESX-1 system. In a previous study, EccB1 structures were determined in two different conformations. Here, two new conformations are identified and described. These four conformations present snapshots of the swinging movement of the membrane-distal domain A2. The movement of this domain involves conformational changes in two flexible loops (loop A, residues 243-264, and loop B, residues 324-341) which are rich in proline and glycine residues and connect domain A2 to domains C1 and B2. It is proposed that the movement of this domain is related to the ATPase activity of EccB1 and its homologues, as well as to the substrate transport of ESX secretion systems. | ||
| - | + | Crystallographic observation of the movement of the membrane-distal domain of the T7SS core component EccB1 from Mycobacterium tuberculosis.,Xie XQ, Zhang XL, Qi C, Li de F, Fleming J, Wang da C, Bi LJ Acta Crystallogr F Struct Biol Commun. 2016 Feb 1;72(Pt 2):139-44. doi:, 10.1107/S2053230X16000212. Epub 2016 Jan 22. PMID:26841765<ref>PMID:26841765</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | [[Category: Bi, L | + | <div class="pdbe-citations 5ebd" style="background-color:#fffaf0;"></div> |
| - | + | == References == | |
| - | + | <references/> | |
| - | [[Category: Li, D | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Bi, L J]] | ||
| + | [[Category: Li, D F]] | ||
[[Category: Qi, C]] | [[Category: Qi, C]] | ||
| + | [[Category: Xie, X Q]] | ||
| + | [[Category: Zhang, X L]] | ||
| + | [[Category: Alpha-beta-alpha sandwich]] | ||
| + | [[Category: Atpase]] | ||
| + | [[Category: Beta-sheet]] | ||
| + | [[Category: Esx-1 secretion system]] | ||
| + | [[Category: Protein transport]] | ||
| + | [[Category: T7ss]] | ||
Revision as of 02:38, 21 February 2016
Crystal structure of EccB1 of Mycobacterium tuberculosis in spacegroup P21 (state IV)
| |||||||||||
