5eub

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'''Unreleased structure'''
 
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The entry 5eub is ON HOLD until Paper Publication
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==Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with 2-amino-MTA and sulfate==
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<StructureSection load='5eub' size='340' side='right' caption='[[5eub]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
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Authors: Cameron, S.A., Firestone, R.S., Schramm, V.L., Almo, S.C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5eub]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EUB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EUB FirstGlance]. <br>
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Description: Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with 2-amino-MTA and sulfate
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5S7:(2~{R},3~{R},4~{S},5~{S})-2-[2,6-BIS(AZANYL)PURIN-9-YL]-5-(METHYLSULFANYLMETHYL)OXOLANE-3,4-DIOL'>5S7</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ozc|3ozc]], [[3ozd|3ozd]], [[1k27|1k27]], [[3oze|3oze]]</td></tr>
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[[Category: Almo, S.C]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/S-methyl-5'-thioadenosine_phosphorylase S-methyl-5'-thioadenosine phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.28 2.4.2.28] </span></td></tr>
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[[Category: Schramm, V.L]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eub OCA], [http://pdbe.org/5eub PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eub RCSB], [http://www.ebi.ac.uk/pdbsum/5eub PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eub ProSAT]</span></td></tr>
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[[Category: Cameron, S.A]]
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</table>
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[[Category: Firestone, R.S]]
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== Disease ==
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[[http://www.uniprot.org/uniprot/MTAP_HUMAN MTAP_HUMAN]] Defects in MTAP are the cause of diaphyseal medullary stenosis with malignant fibrous histiocytoma (DMSMFH) [MIM:[http://omim.org/entry/112250 112250]]. An autosomal dominant bone dysplasia characterized by pathologic fractures due to abnormal cortical growth and diaphyseal medullary stenosis. The fractures heal poorly, and there is progressive bowing of the lower extremities. Some patients show a limb-girdle myopathy, with muscle weakness and atrophy. Approximately 35% of affected individuals develop an aggressive form of bone sarcoma consistent with malignant fibrous histiocytoma or osteosarcoma. Note=DMSMFH causing mutations found in MTAP exon 9 result in exon skipping and dysregulated alternative splicing of all MTAP isoforms (PubMed:22464254).<ref>PMID:22464254</ref> Note=Loss of MTAP activity may play a role in human cancer. MTAP loss has been reported in a number of cancers, including osteosarcoma, malignant melanoma and gastric cancer.[HAMAP-Rule:MF_03155]
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== Function ==
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[[http://www.uniprot.org/uniprot/MTAP_HUMAN MTAP_HUMAN]] Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.<ref>PMID:3091600</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: S-methyl-5'-thioadenosine phosphorylase]]
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[[Category: Almo, S C]]
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[[Category: Cameron, S A]]
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[[Category: Firestone, R S]]
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[[Category: Schramm, V L]]
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[[Category: Phosphorylase]]
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[[Category: Transferase-transferase substrate complex]]

Revision as of 21:36, 22 December 2016

Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with 2-amino-MTA and sulfate

5eub, resolution 1.81Å

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