1aei
From Proteopedia
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'''CRYSTAL STRUCTURE OF THE ANNEXIN XII HEXAMER''' | '''CRYSTAL STRUCTURE OF THE ANNEXIN XII HEXAMER''' | ||
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[[Category: Mailliard, W S.]] | [[Category: Mailliard, W S.]] | ||
[[Category: Schlaepfer, D D.]] | [[Category: Schlaepfer, D D.]] | ||
| - | [[Category: | + | [[Category: Annexin]] |
| - | [[Category: | + | [[Category: Calcium]] |
| - | [[Category: | + | [[Category: Calcium/phospholipid-binding]] |
| - | [[Category: | + | [[Category: Phospholipid]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:09:54 2008'' | |
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Revision as of 07:09, 2 May 2008
CRYSTAL STRUCTURE OF THE ANNEXIN XII HEXAMER
Overview
Annexins are a family of calcium- and phospholipid-binding proteins implicated in a number of biological processes including membrane fusion and ion channel formation. The crystal structure of the annexin XII hexamer, refined at 2.8 A resolution, forms a concave disk with 3-2 symmetry, about 100 A in diameter and 70 A thick with a central hydrophilic pore. Six intermolecular Ca2+ ions are involved in hexamer formation. An additional 18 Ca2+ ions are located on the perimeter of the disk, accessible only from the side of the hexameric disk. On the basis of the hexamer structure we propose here a new mode of protein-phospholipid bilayer interaction that is distinct from the hydrophobic insertion of typical membrane proteins. This speculative model postulates the Ca(2+)-dependent insertion of the hydrophilic annexin XII hexamer into phospholipid bilayers with local reorientation of the bilayer phospholipids.
About this Structure
1AEI is a Single protein structure of sequence from Hydra vulgaris. Full crystallographic information is available from OCA.
Reference
Crystal structure of the annexin XII hexamer and implications for bilayer insertion., Luecke H, Chang BT, Mailliard WS, Schlaepfer DD, Haigler HT, Nature. 1995 Nov 30;378(6556):512-5. PMID:7477411 Page seeded by OCA on Fri May 2 10:09:54 2008
