5ex7

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m (Protected "5ex7" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==Crystal structure of Brat NHL domain in complex with an 8-nt hunchback mRNA==
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<StructureSection load='5ex7' size='340' side='right' caption='[[5ex7]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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The entry 5ex7 is ON HOLD
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ex7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EX7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EX7 FirstGlance]. <br>
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Authors: Wang, Y., Yu, Z., Wang, M., Liu, C.P., Yang, N., Xu, R.M.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ex7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ex7 OCA], [http://pdbe.org/5ex7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ex7 RCSB], [http://www.ebi.ac.uk/pdbsum/5ex7 PDBsum]</span></td></tr>
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</table>
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Description: Crystal structure of Brat NHL domain in complex with an 8-nt hunchback mRNA
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== Function ==
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[[Category: Unreleased Structures]]
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[[http://www.uniprot.org/uniprot/BRAT_DROME BRAT_DROME]] Plays a central role in translation repression of hb mRNA by being recruited by nos and pum to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR. Probably recruited by other proteins to repress translation of other mRNAs in other tissues. Involved in the regulation of ribosomal RNA synthesis and cell growth. Participates in abdominal segmentation and imaginal disk development. Involved in brain tumor suppression, by acting as a growth suppressor in the larval brain.<ref>PMID:11274060</ref> <ref>PMID:11807032</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Liu, C P]]
[[Category: Wang, M]]
[[Category: Wang, M]]
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[[Category: Yu, Z]]
 
[[Category: Wang, Y]]
[[Category: Wang, Y]]
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[[Category: Xu, R.M]]
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[[Category: Xu, R M]]
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[[Category: Liu, C.P]]
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[[Category: Yang, N]]
[[Category: Yang, N]]
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[[Category: Yu, Z]]
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[[Category: Brat-nhl]]
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[[Category: Hunchback mrna]]
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[[Category: Translation-rna complex]]

Revision as of 13:50, 9 December 2015

Crystal structure of Brat NHL domain in complex with an 8-nt hunchback mRNA

5ex7, resolution 2.60Å

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