This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ahf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1ahf.gif|left|200px]]
[[Image:1ahf.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1ahf |SIZE=350|CAPTION= <scene name='initialview01'>1ahf</scene>, resolution 2.3&Aring;
+
The line below this paragraph, containing "STRUCTURE_1ahf", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=IOP:INDOLYLPROPIONIC+ACID'>IOP</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5&#39;-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate_transaminase Aspartate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.1 2.6.1.1] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1ahf| PDB=1ahf | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ahf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ahf OCA], [http://www.ebi.ac.uk/pdbsum/1ahf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ahf RCSB]</span>
+
-
}}
+
'''ASPARTATE AMINOTRANSFERASE HEXAMUTANT'''
'''ASPARTATE AMINOTRANSFERASE HEXAMUTANT'''
Line 28: Line 25:
[[Category: Jansonius, J N.]]
[[Category: Jansonius, J N.]]
[[Category: Malashkevich, V N.]]
[[Category: Malashkevich, V N.]]
-
[[Category: transferase (aminotransferase)]]
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:16:27 2008''
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:40:20 2008''
+

Revision as of 07:16, 2 May 2008

Image:1ahf.gif

Template:STRUCTURE 1ahf

ASPARTATE AMINOTRANSFERASE HEXAMUTANT


Overview

Mutation of six residues of Escherichia coli aspartate aminotransferase results in substantial acquisition of the transamination properties of tyrosine amino-transferase without loss of aspartate transaminase activity. X-ray crystallographic analysis of key inhibitor complexes of the hexamutant reveals the structural basis for this substrate selectivity. It appears that tyrosine aminotransferase achieves nearly equal affinities for a wide range of amino acids by an unusual conformational switch. An active-site arginine residue either shifts its position to electrostatically interact with charged substrates or moves aside to allow access of aromatic ligands.

About this Structure

1AHF is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Alternating arginine-modulated substrate specificity in an engineered tyrosine aminotransferase., Malashkevich VN, Onuffer JJ, Kirsch JF, Jansonius JN, Nat Struct Biol. 1995 Jul;2(7):548-53. PMID:7664122 Page seeded by OCA on Fri May 2 10:16:27 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ahf"
Personal tools