Catabolite control protein
From Proteopedia
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== Function == | == Function == | ||
| - | '''Catabolite control protein''' (CcpA) is a regulator of carbon metabolism in gram-positive bacteria. When high concentrations of glucose-6 phosphate or fructose-1,6-diphosphate are present in the cell, they phosphorylate proteins HPr or Crh which interact with CcpA. The latter binds to DNA operator to modulate transcription.<ref>PMID:16321938</ref> | + | '''Catabolite control protein''' (CcpA) or '''glucose-resistant amylase regulator''' is a regulator of carbon metabolism in gram-positive bacteria. When high concentrations of glucose-6 phosphate or fructose-1,6-diphosphate are present in the cell, they phosphorylate proteins HPr or Crh which interact with CcpA. The latter binds to DNA operator to modulate transcription.<ref>PMID:16321938</ref> |
== Structural highlights == | == Structural highlights == | ||
CcpA phosphorylation activity is carried out by a <scene name='57/570565/Cv/2'>phosphorylated Ser residue</scene> (PDB entry [[2fep]]).<ref>PMID:8195089</ref> <ref>PMID:8596444</ref> | CcpA phosphorylation activity is carried out by a <scene name='57/570565/Cv/2'>phosphorylated Ser residue</scene> (PDB entry [[2fep]]).<ref>PMID:8195089</ref> <ref>PMID:8596444</ref> | ||
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| + | ==3D structures of catabolite control protein== | ||
| + | [[Catabolite control protein 3D structures]] | ||
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</StructureSection> | </StructureSection> | ||
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**[[2oen]] - BmCcpA + phosphocarrier protein HPr <br /> | **[[2oen]] - BmCcpA + phosphocarrier protein HPr <br /> | ||
**[[2fep]] - BsCcpA + phosphocarrier protein HPr – ''Bacillus subtilis''<br /> | **[[2fep]] - BsCcpA + phosphocarrier protein HPr – ''Bacillus subtilis''<br /> | ||
| + | **[[4rk6]] - WpCcpA + glucose – ''Weissella paramesenteroides'' <br /> | ||
| + | **[[4rk7]] - WpCcpA + sucrose <br /> | ||
*CcpA ternary complex | *CcpA ternary complex | ||
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**[[1zvv]] – BsCcpA + catabolite repression Crh + DNA <br /> | **[[1zvv]] – BsCcpA + catabolite repression Crh + DNA <br /> | ||
**[[3oqm]], [[3oqn]], [[3oqo]] - BsCcpA + phosphocarrier protein HPr + DNA<br /> | **[[3oqm]], [[3oqn]], [[3oqo]] - BsCcpA + phosphocarrier protein HPr + DNA<br /> | ||
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| + | *CcpC | ||
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| + | **[[5z72]] - CcpC + citrate – ''Bacillus velezensis''<br /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:33, 28 April 2019
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3D structures of catabolite control protein
Updated on 28-April-2019
References
- ↑ Iyer R, Baliga NS, Camilli A. Catabolite control protein A (CcpA) contributes to virulence and regulation of sugar metabolism in Streptococcus pneumoniae. J Bacteriol. 2005 Dec;187(24):8340-9. PMID:16321938 doi:http://dx.doi.org/10.1128/JB.187.24.8340-8349.2005
- ↑ Deutscher J, Reizer J, Fischer C, Galinier A, Saier MH Jr, Steinmetz M. Loss of protein kinase-catalyzed phosphorylation of HPr, a phosphocarrier protein of the phosphotransferase system, by mutation of the ptsH gene confers catabolite repression resistance to several catabolic genes of Bacillus subtilis. J Bacteriol. 1994 Jun;176(11):3336-44. PMID:8195089
- ↑ Fujita Y, Miwa Y, Galinier A, Deutscher J. Specific recognition of the Bacillus subtilis gnt cis-acting catabolite-responsive element by a protein complex formed between CcpA and seryl-phosphorylated HPr. Mol Microbiol. 1995 Sep;17(5):953-60. PMID:8596444
