Catechol O-methyltransferase
From Proteopedia
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== Function == | == Function == | ||
| - | '''Catechol O-methyltransferase''' (COMT) methylates catecholamines like dopamine, epinephrine and norepinephrine. The cofactor S-adenosyl-L-methionine (SAM) serves as the methyl donor in the reaction and is converted to to S-adenosyl-L-homocysteine (SAH) by the reaction. | + | '''Catechol O-methyltransferase''' (COMT) methylates catecholamines like dopamine, epinephrine and norepinephrine. The cofactor S-adenosyl-L-methionine (SAM) serves as the methyl donor in the reaction and is converted to to S-adenosyl-L-homocysteine (SAH) by the reaction.<ref>PMID:19111934</ref> |
== Relevance == | == Relevance == | ||
| - | The Parkinson Disease drug levodopa is a substrate of COMT and COMT inhibitors like entacapone are used with levodopa in the disease treatment.<ref>PMID: | + | The Parkinson Disease drug levodopa is a substrate of COMT and COMT inhibitors like entacapone are used with levodopa in the disease treatment.<ref>PMID:25559423</ref> |
==Structural highlights == | ==Structural highlights == | ||
Revision as of 09:08, 6 December 2015
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3D Structures of catechol O-methyltransferase
Updated on 06-December-2015
References
- ↑ Tsuji E, Okazaki K, Isaji M, Takeda K. Crystal structures of the Apo and Holo form of rat catechol-O-methyltransferase. J Struct Biol. 2008 Dec 10. PMID:19111934 doi:S1047-8477(08)00293-1
- ↑ Muller T. Catechol-O-methyltransferase inhibitors in Parkinson's disease. Drugs. 2015 Feb;75(2):157-74. doi: 10.1007/s40265-014-0343-0. PMID:25559423 doi:http://dx.doi.org/10.1007/s40265-014-0343-0
