1ak2

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[[Image:1ak2.gif|left|200px]]
[[Image:1ak2.gif|left|200px]]
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{{Structure
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|PDB= 1ak2 |SIZE=350|CAPTION= <scene name='initialview01'>1ak2</scene>, resolution 1.92&Aring;
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The line below this paragraph, containing "STRUCTURE_1ak2", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_kinase Adenylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.3 2.7.4.3] </span>
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{{STRUCTURE_1ak2| PDB=1ak2 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ak2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ak2 OCA], [http://www.ebi.ac.uk/pdbsum/1ak2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ak2 RCSB]</span>
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'''ADENYLATE KINASE ISOENZYME-2'''
'''ADENYLATE KINASE ISOENZYME-2'''
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[[Category: Schlauderer, G J.]]
[[Category: Schlauderer, G J.]]
[[Category: Schulz, G E.]]
[[Category: Schulz, G E.]]
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[[Category: nucleoside monophosphate kinase]]
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[[Category: Nucleoside monophosphate kinase]]
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[[Category: phosphotransferase]]
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[[Category: Phosphotransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:22:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:41:57 2008''
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Revision as of 07:22, 2 May 2008

Image:1ak2.gif

Template:STRUCTURE 1ak2

ADENYLATE KINASE ISOENZYME-2


Overview

In vertebrates, there are different adenylate kinases in the compartments cytosol, mitochondrial intermembrane space, and mitochondrial matrix. Here, we report the spatial structure of the intermembrane species established in two crystal forms by X-ray diffraction analyses at 1.92 and 2.1 A resolution. In both structures, the enzyme is unligated, and thus in an "open" conformation. The enzyme was prepared from bovine liver, containing at least five variants arisen from posttranscriptional and posttranslational modifications. It could only be crystallized after removing some of these variants. A comparison with the known structures of the adenylate kinases from cytosol and mitochondrial matrix reveals structural differences that should play a role in protein targeting because none of these enzymes contains a cleavable signal peptide. A further comparison with adenylate kinases from Gram-positive bacteria showed that the structural Zn2+ ion of these species is replaced by a strictly conserved assembly of hydrogen bonded residues.

About this Structure

1AK2 is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

The structure of bovine mitochondrial adenylate kinase: comparison with isoenzymes in other compartments., Schlauderer GJ, Schulz GE, Protein Sci. 1996 Mar;5(3):434-41. PMID:8868479 Page seeded by OCA on Fri May 2 10:22:19 2008

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