1ak6
From Proteopedia
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'''DESTRIN, NMR, MINIMIZED AVERAGE STRUCTURE''' | '''DESTRIN, NMR, MINIMIZED AVERAGE STRUCTURE''' | ||
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[[Category: Ogura, K.]] | [[Category: Ogura, K.]] | ||
[[Category: Yahara, I.]] | [[Category: Yahara, I.]] | ||
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| - | [[Category: | + | [[Category: Actin-binding protein]] |
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Revision as of 07:22, 2 May 2008
DESTRIN, NMR, MINIMIZED AVERAGE STRUCTURE
Overview
Destrin is an isoprotein of cofilin that regulates actin cytoskeleton in various eukaryotes. We determined the tertiary structure of destrin by triple-resonance multidimensional nuclear magnetic resonance. In spite of there being no significant amino acid sequence homology, we found that the folding of destrin was strikingly similar to that of repeated segments in the gelsolin family, which resulted in a new protein fold group. Sequential dissimilarity of the actin-binding helix of destrin to that of gelsolin explains the Ca2+-independent actin-binding of destrin. Possible mechanisms of phosphorylation-sensitive phosphoinositide-competitive actin binding, of pH-dependent filament severing, and of nuclear translocation with actin in response to stresses, are discussed on the basis of the tertiary structure.
About this Structure
1AK6 is a Single protein structure of sequence from Homo sapiens and sus scrofa. Full crystallographic information is available from OCA.
Reference
Tertiary structure of destrin and structural similarity between two actin-regulating protein families., Hatanaka H, Ogura K, Moriyama K, Ichikawa S, Yahara I, Inagaki F, Cell. 1996 Jun 28;85(7):1047-55. PMID:8674111 Page seeded by OCA on Fri May 2 10:22:32 2008
