Choline O-acetyltransferase
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | |||
<StructureSection load='2fy3' size='350' side='right' caption='Human choline O-acetyltransferase complex with choline (PDB entry [[2fy3]])' scene=''> | <StructureSection load='2fy3' size='350' side='right' caption='Human choline O-acetyltransferase complex with choline (PDB entry [[2fy3]])' scene=''> | ||
| Line 5: | Line 4: | ||
== Function == | == Function == | ||
| - | '''Choline O-acetyltransferase''' (ChaT) catalyzes the synthesis of acetyl-CoA and choline to form the neurotransmitter acetylcholine. ChaT is found in nerve terminals. | + | '''Choline O-acetyltransferase''' (ChaT) catalyzes the synthesis of acetyl-CoA and choline to form the neurotransmitter acetylcholine. ChaT is found in nerve terminals.<ref>PMID:10594838</ref> |
| + | |||
| + | == Disease == | ||
| + | |||
| + | Mutations in human ChaT are linked to congenital mysthenic syndrome. The concentration of ChaT is reduced in brains of Alzheimer's Disease and ALS patients. | ||
| + | |||
| + | == Structural highlights == | ||
| + | |||
</StructureSection> | </StructureSection> | ||
Revision as of 07:39, 8 December 2015
| |||||||||||
3D Structures of choline O-acetyltransferase
Updated on 08-December-2015
2fy2 – hChaT – human
2fy3 – hChaT + choline
2fy4 – hChaT + CoA
2fy5 – hChaT + CoA derivative
