Choline O-acetyltransferase
From Proteopedia
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<StructureSection load='2fy3' size='350' side='right' caption='Human choline O-acetyltransferase complex with choline (PDB entry [[2fy3]])' scene=''> | <StructureSection load='2fy3' size='350' side='right' caption='Human choline O-acetyltransferase complex with choline (PDB entry [[2fy3]])' scene=''> | ||
__TOC__ | __TOC__ | ||
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== Structural highlights == | == Structural highlights == | ||
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| + | Human ChaT contains 2 domains: substrate-binding and catalytic domain. The active site is a tunnel in which acetyl-CoA is bound at the surface and the choline at the interior pocket.<ref>PMID:17144655</ref> | ||
</StructureSection> | </StructureSection> | ||
Revision as of 07:58, 8 December 2015
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3D Structures of choline O-acetyltransferase
Updated on 08-December-2015
2fy2 – hChaT – human
2fy3 – hChaT + choline
2fy4 – hChaT + CoA
2fy5 – hChaT + CoA derivative
References
- ↑ Oda Y. Choline acetyltransferase: the structure, distribution and pathologic changes in the central nervous system. Pathol Int. 1999 Nov;49(11):921-37. PMID:10594838
- ↑ Kim AR, Rylett RJ, Shilton BH. Substrate binding and catalytic mechanism of human choline acetyltransferase. Biochemistry. 2006 Dec 12;45(49):14621-31. PMID:17144655 doi:10.1021/bi061536l
