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Antithrombin
From Proteopedia
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▪ '''AT-I''' refers to the absorption of thrombin to fibrin.<br /> | ▪ '''AT-I''' refers to the absorption of thrombin to fibrin.<br /> | ||
▪ '''AT-II''' and heparin interfere with the interaction of thrombin and fibrinogen.<br /> | ▪ '''AT-II''' and heparin interfere with the interaction of thrombin and fibrinogen.<br /> | ||
| - | ▪ '''AT-III''' inactivates thrombin in plasma.<br /> | + | ▪ '''AT-III''' inactivates thrombin in plasma. For details see [[Student Projects for UMass Chemistry 423 Spring 2012-7]].<br /> |
▪ '''AT-IV''' becomes activated during blood coagulation.<br /> | ▪ '''AT-IV''' becomes activated during blood coagulation.<br /> | ||
See details for the antithrombin pentasaccharide complex in [[Molecular Playground/Antithrombin-Heparin]]. | See details for the antithrombin pentasaccharide complex in [[Molecular Playground/Antithrombin-Heparin]]. | ||
Revision as of 11:22, 22 February 2016
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3D structures of antithrombin
Updated on 22-February-2016
References
- ↑ Li W, Johnson DJ, Esmon CT, Huntington JA. Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin. Nat Struct Mol Biol. 2004 Sep;11(9):857-62. Epub 2004 Aug 15. PMID:15311269 doi:10.1038/nsmb811
