1ald

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[[Image:1ald.gif|left|200px]]
[[Image:1ald.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1ald", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphate_aldolase Fructose-bisphosphate aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.13 4.1.2.13] </span>
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{{STRUCTURE_1ald| PDB=1ald | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ald FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ald OCA], [http://www.ebi.ac.uk/pdbsum/1ald PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ald RCSB]</span>
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'''ACTIVITY AND SPECIFICITY OF HUMAN ALDOLASES'''
'''ACTIVITY AND SPECIFICITY OF HUMAN ALDOLASES'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Watson, H C.]]
[[Category: Watson, H C.]]
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[[Category: lyase (aldehyde)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:25:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:42:46 2008''
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Revision as of 07:25, 2 May 2008

Image:1ald.gif

Template:STRUCTURE 1ald

ACTIVITY AND SPECIFICITY OF HUMAN ALDOLASES


Overview

The structure of the type I fructose 1,6-bisphosphate aldolase from human muscle has been extended from 3 A to 2 A resolution. The improvement in the resulting electron density map is such that the 20 or so C-terminal residues, known to be associated with activity and isozyme specificity, have been located. The side-chain of the Schiff's base-forming lysine 229 is located towards the centre of an eight-stranded beta-barrel type structure. The C-terminal "tail" extends from the rim of the beta-barrel towards lysine 229, thus forming part of the active site of the enzyme. This structural arrangement appears to explain the difference in activity and specificity of the three tissue-specific human aldolases and helps with our understanding of the type I aldolase reaction mechanism.

About this Structure

1ALD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Activity and specificity of human aldolases., Gamblin SJ, Davies GJ, Grimes JM, Jackson RM, Littlechild JA, Watson HC, J Mol Biol. 1991 Jun 20;219(4):573-6. PMID:2056525 Page seeded by OCA on Fri May 2 10:25:10 2008

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