1alv

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[[Image:1alv.gif|left|200px]]
[[Image:1alv.gif|left|200px]]
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{{Structure
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|PDB= 1alv |SIZE=350|CAPTION= <scene name='initialview01'>1alv</scene>, resolution 1.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1alv", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.52 and 3.4.22.53 3.4.22.52 and 3.4.22.53] </span>
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{{STRUCTURE_1alv| PDB=1alv | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1alv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1alv OCA], [http://www.ebi.ac.uk/pdbsum/1alv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1alv RCSB]</span>
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'''CALCIUM BOUND DOMAIN VI OF PORCINE CALPAIN'''
'''CALCIUM BOUND DOMAIN VI OF PORCINE CALPAIN'''
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[[Category: Maki, M.]]
[[Category: Maki, M.]]
[[Category: Narayana, S V.L.]]
[[Category: Narayana, S V.L.]]
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[[Category: calcium binding]]
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[[Category: Calcium binding]]
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[[Category: calmodulin like]]
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[[Category: Calmodulin like]]
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[[Category: domain of cystein protease]]
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[[Category: Domain of cystein protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:43:04 2008''
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Revision as of 07:25, 2 May 2008

Image:1alv.gif

Template:STRUCTURE 1alv

CALCIUM BOUND DOMAIN VI OF PORCINE CALPAIN


Overview

The three dimensional structure of calcium-bound domain VI of porcine calpain has been determined to 1.9 A resolution. The crystal structure reveals five EF-hands, one more than previously suggested. There are two EF-hand pairs, one pair (EF1-EF2) displays an 'open' conformation and the other (EF3-EF4) a 'closed' conformation. Unusually, a calcium atom is found at the C-terminal end of the calcium binding loop of EF4. With two additional residues in the calcium binding loop, the fifth EF-hand (EF5) is in a 'closed' conformation. EF5 pairs up with the corresponding fifth EF-hand of a non-crystallographically related molecule. Considering the EF5's role in a homodimer formation of domain VI, we suggest a model for the assembly of heterodimeric calpain. The crystal structure of a Ca2+ bound domain VI-inhibitor (PD150606) complex has been refined to 2.1 A resolution. A possible mode for calpain inhibition is discussed.

About this Structure

1ALV is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Crystal structure of calcium bound domain VI of calpain at 1.9 A resolution and its role in enzyme assembly, regulation, and inhibitor binding., Lin GD, Chattopadhyay D, Maki M, Wang KK, Carson M, Jin L, Yuen PW, Takano E, Hatanaka M, DeLucas LJ, Narayana SV, Nat Struct Biol. 1997 Jul;4(7):539-47. PMID:9228946 Page seeded by OCA on Fri May 2 10:25:49 2008

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