5emv
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of the palmitoylated human TEAD2 transcription factor== |
| - | + | <StructureSection load='5emv' size='340' side='right' caption='[[5emv]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5emv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EMV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EMV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=P1L:S-PALMITOYL-L-CYSTEINE'>P1L</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5emw|5emw]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5emv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5emv OCA], [http://pdbe.org/5emv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5emv RCSB], [http://www.ebi.ac.uk/pdbsum/5emv PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[ | + | == Function == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/TEAD2_HUMAN TEAD2_HUMAN]] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.<ref>PMID:18579750</ref> <ref>PMID:19324877</ref> |
| - | [[ | + | == References == |
| - | [[Category: Cunningham, C | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cunningham, C N]] | ||
[[Category: Dey, A]] | [[Category: Dey, A]] | ||
| + | [[Category: Fairbrother, W J]] | ||
[[Category: Gierke, S]] | [[Category: Gierke, S]] | ||
| - | [[Category: | + | [[Category: Hannoush, R N]] |
| - | [[Category: | + | [[Category: Murray, J]] |
| - | [[Category: Noland, C | + | [[Category: Noland, C L]] |
| - | [[Category: Schnier, P | + | [[Category: Sagolla, M]] |
| + | [[Category: Sandoval, W N]] | ||
| + | [[Category: Schnier, P D]] | ||
| + | [[Category: Palmitoylated protein]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 12:49, 23 December 2015
Crystal structure of the palmitoylated human TEAD2 transcription factor
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