1amx

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[[Image:1amx.jpg|left|200px]]
[[Image:1amx.jpg|left|200px]]
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{{Structure
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|PDB= 1amx |SIZE=350|CAPTION= <scene name='initialview01'>1amx</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1amx", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=CBR:Collagen-Binding+Residues+Identified+By+Site-Directed+Mu+...'>CBR</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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|GENE= CNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])
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|DOMAIN=
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{{STRUCTURE_1amx| PDB=1amx | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1amx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1amx OCA], [http://www.ebi.ac.uk/pdbsum/1amx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1amx RCSB]</span>
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}}
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'''COLLAGEN-BINDING DOMAIN FROM A STAPHYLOCOCCUS AUREUS ADHESIN'''
'''COLLAGEN-BINDING DOMAIN FROM A STAPHYLOCOCCUS AUREUS ADHESIN'''
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[[Category: Narayana, S.]]
[[Category: Narayana, S.]]
[[Category: Symersky, J.]]
[[Category: Symersky, J.]]
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[[Category: bacterial adhesin]]
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[[Category: Bacterial adhesin]]
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[[Category: mscramm]]
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[[Category: Mscramm]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:27:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:43:34 2008''
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Revision as of 07:27, 2 May 2008

Image:1amx.jpg

Template:STRUCTURE 1amx

COLLAGEN-BINDING DOMAIN FROM A STAPHYLOCOCCUS AUREUS ADHESIN


Overview

The crystal structure of the recombinant 19,000 M(r) binding domain from the Staphylococcus aureus collagen adhesin has been determined at 2 A resolution. The domain fold is a jelly-roll, composed of two antiparallel beta-sheets and two short alpha-helices. Triple-helical collagen model probes were used in a systematic docking search to identify the collagen-binding site. A groove on beta-sheet I exhibited the best surface complementarity to the collagen probes. This site partially overlaps with the peptide sequence previously shown to be critical for collagen binding. Recombinant proteins containing single amino acid mutations designed to disrupt the surface of the putative binding site exhibited significantly lower affinities for collagen. Here we present a structural perspective for the mode of collagen binding by a bacterial surface protein.

About this Structure

1AMX is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Structure of the collagen-binding domain from a Staphylococcus aureus adhesin., Symersky J, Patti JM, Carson M, House-Pompeo K, Teale M, Moore D, Jin L, Schneider A, DeLucas LJ, Hook M, Narayana SV, Nat Struct Biol. 1997 Oct;4(10):833-8. PMID:9334749 Page seeded by OCA on Fri May 2 10:27:55 2008

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