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1ao7

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[[Image:1ao7.gif|left|200px]]
[[Image:1ao7.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1ao7", creates the "Structure Box" on the page.
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|GENE= HLA-A 0201 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), V BETA 12.3 [BV13S1] - D BETA 2.1 - J BETA 2.1 - ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), V ALPHA 2.3 [AV2S1A2] - J ALPHA 24 - C ALPHA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), V BETA 12.3 [BV13S1] - D BETA 2.1 - J BETA 2.1 - C BETA 2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_1ao7| PDB=1ao7 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ao7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ao7 OCA], [http://www.ebi.ac.uk/pdbsum/1ao7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ao7 RCSB]</span>
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'''COMPLEX BETWEEN HUMAN T-CELL RECEPTOR, VIRAL PEPTIDE (TAX), AND HLA-A 0201'''
'''COMPLEX BETWEEN HUMAN T-CELL RECEPTOR, VIRAL PEPTIDE (TAX), AND HLA-A 0201'''
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[[Category: Utz, U.]]
[[Category: Utz, U.]]
[[Category: Wiley, D C.]]
[[Category: Wiley, D C.]]
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[[Category: class i mhc]]
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[[Category: Class i mhc]]
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[[Category: complex (mhc/viral peptide/receptor]]
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[[Category: T-cell receptor]]
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[[Category: t-cell receptor]]
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[[Category: Viral peptide]]
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[[Category: viral peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:30:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:44:18 2008''
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Revision as of 07:30, 2 May 2008

Image:1ao7.gif

Template:STRUCTURE 1ao7

COMPLEX BETWEEN HUMAN T-CELL RECEPTOR, VIRAL PEPTIDE (TAX), AND HLA-A 0201


Overview

Recognition by a T-cell antigen receptor (TCR) of peptide complexed with a major histocompatibility complex (MHC) molecule occurs through variable loops in the TCR structure which bury almost all the available peptide and a much larger area of the MHC molecule. The TCR fits diagonally across the MHC peptide-binding site in a surface feature common to all class I and class II MHC molecules, providing evidence that the nature of binding is general. A broadly applicable binding mode has implications for the mechanism of repertoire selection and the magnitude of alloreactions.

About this Structure

1AO7 is a Protein complex structure of sequences from Homo sapiens and Human t-lymphotropic virus 1. Full crystallographic information is available from OCA.

Reference

Structure of the complex between human T-cell receptor, viral peptide and HLA-A2., Garboczi DN, Ghosh P, Utz U, Fan QR, Biddison WE, Wiley DC, Nature. 1996 Nov 14;384(6605):134-41. PMID:8906788 Page seeded by OCA on Fri May 2 10:30:10 2008

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OCA

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