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1aoj
From Proteopedia
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[[Image:1aoj.gif|left|200px]] | [[Image:1aoj.gif|left|200px]] | ||
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'''THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER''' | '''THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER''' | ||
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[[Category: Kishan, K V.R.]] | [[Category: Kishan, K V.R.]] | ||
[[Category: Newcomer, M E.]] | [[Category: Newcomer, M E.]] | ||
| - | [[Category: | + | [[Category: Eps8]] |
| - | [[Category: | + | [[Category: Proline rich peptide]] |
| - | [[Category: | + | [[Category: Sh3 domain]] |
| - | [[Category: | + | [[Category: Signal transduction]] |
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Revision as of 07:31, 2 May 2008
THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER
Overview
SH3 domains are structurally well-characterized as monomeric modular units of protein structure that mediate protein-protein recognition in numerous signal transduction proteins. The X-ray crystallographic structure of the Eps8 SH3 domain reveals a novel variation of the canonical SH3 fold: the SH3 domain from Eps8 is a dimer formed by strand interchange. In addition, co-immunoprecipitation experiments show that intact Eps8 is multimeric in vivo. Hence, the SH3 domain of Eps8 may represent a dimerization motif.
About this Structure
1AOJ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
The SH3 domain of Eps8 exists as a novel intertwined dimer., Kishan KV, Scita G, Wong WT, Di Fiore PP, Newcomer ME, Nat Struct Biol. 1997 Sep;4(9):739-43. PMID:9303002 Page seeded by OCA on Fri May 2 10:31:00 2008
