This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1aol
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1aol.gif|left|200px]] | [[Image:1aol.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1aol", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | | | + | --> |
| - | + | {{STRUCTURE_1aol| PDB=1aol | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''FRIEND MURINE LEUKEMIA VIRUS RECEPTOR-BINDING DOMAIN''' | '''FRIEND MURINE LEUKEMIA VIRUS RECEPTOR-BINDING DOMAIN''' | ||
| Line 31: | Line 28: | ||
[[Category: Hamson, C A.]] | [[Category: Hamson, C A.]] | ||
[[Category: Kim, P S.]] | [[Category: Kim, P S.]] | ||
| - | [[Category: | + | [[Category: Coat protein]] |
| - | [[Category: | + | [[Category: Retrovirus]] |
| - | [[Category: | + | [[Category: Viral glycoprotein]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:31:05 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 07:31, 2 May 2008
FRIEND MURINE LEUKEMIA VIRUS RECEPTOR-BINDING DOMAIN
Overview
An essential step in retrovirus infection is the binding of the virus to its receptor on a target cell. The structure of the receptor-binding domain of the envelope glycoprotein from Friend murine leukemia virus was determined to 2.0 angstrom resolution by x-ray crystallography. The core of the domain is an antiparallel beta sandwich, with two interstrand loops forming a helical subdomain atop the sandwich. The residues in the helical region, but not in the beta sandwich, are highly variable among mammalian C-type retroviruses with distinct tropisms, indicating that the helical subdomain determines the receptor specificity of the virus.
About this Structure
1AOL is a Single protein structure of sequence from Friend murine leukemia virus. Full crystallographic information is available from OCA.
Reference
Structure of a murine leukemia virus receptor-binding glycoprotein at 2.0 angstrom resolution., Fass D, Davey RA, Hamson CA, Kim PS, Cunningham JM, Berger JM, Science. 1997 Sep 12;277(5332):1662-6. PMID:9287219 Page seeded by OCA on Fri May 2 10:31:05 2008
