5f5a
From Proteopedia
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- | ''' | + | ==Crystal Structure of human JMJD2D complexed with KDOAM16== |
- | + | <StructureSection load='5f5a' size='340' side='right' caption='[[5f5a]], [[Resolution|resolution]] 1.41Å' scene=''> | |
- | + | == Structural highlights == | |
- | + | <table><tr><td colspan='2'>[[5f5a]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F5A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F5A FirstGlance]. <br> | |
- | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5V0:2-[(FURAN-2-YLMETHYLAMINO)METHYL]PYRIDINE-4-CARBOXYLIC+ACID'>5V0</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
- | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f5a OCA], [http://pdbe.org/5f5a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f5a RCSB], [http://www.ebi.ac.uk/pdbsum/5f5a PDBsum]</span></td></tr> | |
- | + | </table> | |
- | [[Category: | + | == Function == |
- | [[Category: | + | [[http://www.uniprot.org/uniprot/KDM4D_HUMAN KDM4D_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref> |
+ | == References == | ||
+ | <references/> | ||
+ | __TOC__ | ||
+ | </StructureSection> | ||
+ | [[Category: Arrowsmith, C H]] | ||
+ | [[Category: Bountra, C]] | ||
+ | [[Category: Bradley, A R]] | ||
+ | [[Category: Brennan, P]] | ||
[[Category: Burgess-Brown, N]] | [[Category: Burgess-Brown, N]] | ||
- | [[Category: | + | [[Category: Burley, S K]] |
+ | [[Category: Crawley, L]] | ||
+ | [[Category: Delft, F von]] | ||
+ | [[Category: Edwards, A]] | ||
[[Category: Krojer, T]] | [[Category: Krojer, T]] | ||
- | [[Category: Bountra, C]] | ||
- | [[Category: Vollmar, M]] | ||
- | [[Category: Burley, S.K]] | ||
- | [[Category: Arrowsmith, C.H]] | ||
[[Category: Oppermann, U]] | [[Category: Oppermann, U]] | ||
+ | [[Category: Ruda, G F]] | ||
+ | [[Category: Structural genomic]] | ||
[[Category: Szykowska, A]] | [[Category: Szykowska, A]] | ||
- | [[Category: | + | [[Category: Vollmar, M]] |
- | [[Category: | + | [[Category: Yang, H]] |
- | [[Category: | + | [[Category: Demethylase]] |
- | [[Category: | + | [[Category: Double-stranded beta helix]] |
- | [[Category: | + | [[Category: Oxidoreductase]] |
- | [[Category: | + | [[Category: Oxygenase]] |
+ | [[Category: Sgc]] |
Revision as of 13:59, 16 December 2015
Crystal Structure of human JMJD2D complexed with KDOAM16
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Categories: Arrowsmith, C H | Bountra, C | Bradley, A R | Brennan, P | Burgess-Brown, N | Burley, S K | Crawley, L | Delft, F von | Edwards, A | Krojer, T | Oppermann, U | Ruda, G F | Structural genomic | Szykowska, A | Vollmar, M | Yang, H | Demethylase | Double-stranded beta helix | Oxidoreductase | Oxygenase | Sgc