5f5i

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m (Protected "5f5i" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==Crystal Structure of human JMJD2A complexed with KDOOA011340==
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<StructureSection load='5f5i' size='340' side='right' caption='[[5f5i]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
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The entry 5f5i is ON HOLD
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5f5i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F5I FirstGlance]. <br>
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Authors: Krojer, T., Vollmar, M., Crawley, L., Szykowska, A., Gileadi, C., Johansson, C., England, K., Yang, H., Burgess-Brown, N., Brennan, P., Burley, S.K., Bountra, C., Arrowsmith, C.H., Edwards, A., Oppermann, U., von Delft, F., Structural Genomics Consortium (SGC)
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5V1:2-[[(PHENYLMETHYL)AMINO]METHYL]PYRIDINE-4-CARBOXYLIC+ACID'>5V1</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f5i OCA], [http://pdbe.org/5f5i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f5i RCSB], [http://www.ebi.ac.uk/pdbsum/5f5i PDBsum]</span></td></tr>
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Description: Crystal Structure of human JMJD2A complexed with KDOOA011340
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</table>
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[[Category: Unreleased Structures]]
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== Function ==
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[[Category: Burgess-Brown, N]]
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[[http://www.uniprot.org/uniprot/KDM4A_HUMAN KDM4A_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref> Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref>
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[[Category: Yang, H]]
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== References ==
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[[Category: Krojer, T]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Bountra, C]]
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[[Category: Vollmar, M]]
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[[Category: Brennan, P]]
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[[Category: Burley, S.K]]
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[[Category: Burgess-Brown, N]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Burley, S K]]
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[[Category: Gileadi, C]]
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[[Category: Oppermann, U]]
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[[Category: Szykowska, A]]
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[[Category: Crawley, L]]
[[Category: Crawley, L]]
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[[Category: Von Delft, F]]
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[[Category: Delft, F von]]
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[[Category: Johansson, C]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Edwards, A]]
[[Category: Edwards, A]]
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[[Category: Brennan, P]]
 
[[Category: England, K]]
[[Category: England, K]]
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[[Category: Gileadi, C]]
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[[Category: Johansson, C]]
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[[Category: Krojer, T]]
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[[Category: Oppermann, U]]
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[[Category: Structural genomic]]
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[[Category: Szykowska, A]]
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[[Category: Vollmar, M]]
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[[Category: Yang, H]]
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[[Category: Demethylase]]
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[[Category: Double-stranded beta helix]]
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[[Category: Oxidoreductase]]
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[[Category: Oxygenase]]
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[[Category: Sgc]]

Revision as of 19:40, 30 December 2015

Crystal Structure of human JMJD2A complexed with KDOOA011340

5f5i, resolution 2.63Å

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