5fpm
From Proteopedia
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| - | + | ==Structure of heat shock-related 70kDA protein 2 with small-molecule ligand 5-phenyl-1,3,4-oxadiazole-2-thiol (AT809) in an alternate binding site.== | |
| - | + | <StructureSection load='5fpm' size='340' side='right' caption='[[5fpm]], [[Resolution|resolution]] 1.96Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5fpm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FPM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FPM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IWT:5-PHENYL-1,3,4-OXADIAZOLE-2-THIOL'>IWT</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fp5|5fp5]], [[5fp6|5fp6]], [[5fpd|5fpd]], [[5fpe|5fpe]], [[5fpn|5fpn]], [[5fpo|5fpo]], [[5fpr|5fpr]], [[5fps|5fps]], [[5fpt|5fpt]], [[5fpy|5fpy]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fpm OCA], [http://pdbe.org/5fpm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fpm RCSB], [http://www.ebi.ac.uk/pdbsum/5fpm PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[ | + | == Function == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/HSP72_HUMAN HSP72_HUMAN]] In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. |
| - | [[ | + | __TOC__ |
| - | [[ | + | </StructureSection> |
| - | [[ | + | |
[[Category: Jhoti, H]] | [[Category: Jhoti, H]] | ||
| + | [[Category: Ludlow, R F]] | ||
| + | [[Category: Patel, S]] | ||
| + | [[Category: Saini, H K]] | ||
| + | [[Category: Tickle, I J]] | ||
| + | [[Category: Verdonk, M]] | ||
| + | [[Category: Alternate binding site]] | ||
| + | [[Category: At809]] | ||
| + | [[Category: Chaperone]] | ||
| + | [[Category: Fragment screening]] | ||
| + | [[Category: Heat shock]] | ||
| + | [[Category: Heat shock-related protein]] | ||
| + | [[Category: Hsp70]] | ||
| + | [[Category: Hspa2]] | ||
| + | [[Category: Protein-ligand complex]] | ||
Revision as of 13:59, 16 December 2015
Structure of heat shock-related 70kDA protein 2 with small-molecule ligand 5-phenyl-1,3,4-oxadiazole-2-thiol (AT809) in an alternate binding site.
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