1apm

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[[Image:1apm.gif|left|200px]]
[[Image:1apm.gif|left|200px]]
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{{Structure
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|PDB= 1apm |SIZE=350|CAPTION= <scene name='initialview01'>1apm</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1apm", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=PO3:PHOSPHITE+ION'>PO3</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1apm| PDB=1apm | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1apm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1apm OCA], [http://www.ebi.ac.uk/pdbsum/1apm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1apm RCSB]</span>
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}}
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'''2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT'''
'''2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT'''
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[[Category: Xuong, N H.]]
[[Category: Xuong, N H.]]
[[Category: Zheng, J.]]
[[Category: Zheng, J.]]
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[[Category: transferase(phosphotransferase)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:33:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:45:04 2008''
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Revision as of 07:33, 2 May 2008

Image:1apm.gif

Template:STRUCTURE 1apm

2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT


Overview

. A mutant (Serl39Ala) of the mouse recombinant catalytic (C) subunit of cAMP-dependent protein kinase was co-crystallized with a peptide inhibitor, PKI(5-24), and MEGA-8 (octanoyl-N-methylglucamide) detergent. This structure was refined using all observed data (30 248 reflections) between 30 and 1.95 A resolution to an R factor of 0.186. R.m.s. deviations of bond lengths and bond angles are 0.013 A and 2.3 degrees, respectively. The final model has 3075 atoms (207 solvent) with a mean B factor of 31.9 A(2). The placement of invariant protein-kinase residues and most C:PKI(5-24) interactions were confirmed, but register errors affecting residues 55-64 and 309-339 were corrected during refinement by shifting the affected sequences toward the C terminus along the previously determined backbone path. New details of C:PKI(5-24) interactions and the Ser338 autophosphorylation site are described, and the acyl group binding site near the catalytic subunit NH(2) terminus is identified.

About this Structure

1APM is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

2.0 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with a peptide inhibitor and detergent., Knighton DR, Bell SM, Zheng J, Ten Eyck LF, Xuong NH, Taylor SS, Sowadski JM, Acta Crystallogr D Biol Crystallogr. 1993 May 1;49(Pt 3):357-61. PMID:15299526 Page seeded by OCA on Fri May 2 10:33:19 2008

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