1aqq

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[[Image:1aqq.jpg|left|200px]]
[[Image:1aqq.jpg|left|200px]]
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{{Structure
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|PDB= 1aqq |SIZE=350|CAPTION= <scene name='initialview01'>1aqq</scene>
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The line below this paragraph, containing "STRUCTURE_1aqq", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=AG:SILVER+ION'>AG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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{{STRUCTURE_1aqq| PDB=1aqq | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aqq OCA], [http://www.ebi.ac.uk/pdbsum/1aqq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1aqq RCSB]</span>
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}}
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'''AG-SUBSTITUTED METALLOTHIONEIN FROM SACCHAROMYCES CEREVISIAE, NMR, 10 STRUCTURES'''
'''AG-SUBSTITUTED METALLOTHIONEIN FROM SACCHAROMYCES CEREVISIAE, NMR, 10 STRUCTURES'''
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[[Category: Narula, S S.]]
[[Category: Narula, S S.]]
[[Category: Peterson, C W.]]
[[Category: Peterson, C W.]]
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[[Category: copper detoxification]]
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[[Category: Copper detoxification]]
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[[Category: metal-thiolate cluster]]
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[[Category: Metal-thiolate cluster]]
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[[Category: metallothionein]]
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[[Category: Metallothionein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:35:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:45:51 2008''
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Revision as of 07:35, 2 May 2008

Template:STRUCTURE 1aqq

AG-SUBSTITUTED METALLOTHIONEIN FROM SACCHAROMYCES CEREVISIAE, NMR, 10 STRUCTURES


Overview

3D solution structural calculations for yeast silver(I)-substituted metallothionein (MT) and native copper(I) MT were completed using experimentally determined NOE and dihedral angle constraints, in conjunction with experimentally derived metal-to-Cys connectivities for AgMT which were assumed identical for CuMT. For the first 40 residues in both structures, the polypeptide backbone wraps around the metal cluster in two large parallel loops separated by a deep cleft containing the metal cluster. Minor differences between the two structures include differences in hydrogen bonds and the orientation of the N-terminus with the overall protein volume conserved to within 6.5%.

About this Structure

1AQQ is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

3D solution structure of copper and silver-substituted yeast metallothioneins., Peterson CW, Narula SS, Armitage IM, FEBS Lett. 1996 Jan 22;379(1):85-93. PMID:8566237 Page seeded by OCA on Fri May 2 10:35:47 2008

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