Chymotrypsin Inhibitor
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
| - | [[Chymotrypsin Inhibitor|Chymotrypsin Inhibitors]] (CI) are serine proteinase inhibitors of chymotrypsin. They are classified by numbers: CI-1<ref>PMID:7922044</ref>, CI-2<ref>PMID:3828302</ref>, CI-3<ref>PMID:10531477</ref>. | + | [[Chymotrypsin Inhibitor|Chymotrypsin Inhibitors]] (CI) are serine proteinase inhibitors of chymotrypsin. They are classified by numbers: CI-1<ref>PMID:7922044</ref>, CI-2<ref>PMID:3828302</ref>, CI-3<ref>PMID:10531477</ref>. '''Subtilisin-chymotrypsin inhibitor''' inhibits both subtilisin and chymotrypsin. |
== Structural highlights == | == Structural highlights == | ||
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**[[2qyi]] – CI-3 (mutant)+cationic trypsin – cow<br /> | **[[2qyi]] – CI-3 (mutant)+cationic trypsin – cow<br /> | ||
**[[1ccv]] – CI –''Apis mellifera'' - NMR<br /> | **[[1ccv]] – CI –''Apis mellifera'' - NMR<br /> | ||
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| + | *Subtilisin-chymotrypsin inhibitor | ||
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| + | **[[5ffn]], [[5fbz]] – CI-2A + subtilase – ''Bacillus''<br /> | ||
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}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:38, 3 April 2017
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3D Structures of Chymotrypsin Inhibitor
Updated on 03-April-2017
References
- ↑ Huang K, Strynadka NC, Bernard VD, Peanasky RJ, James MN. The molecular structure of the complex of Ascaris chymotrypsin/elastase inhibitor with porcine elastase. Structure. 1994 Jul 15;2(7):679-89. PMID:7922044
- ↑ McPhalen CA, James MN. Crystal and molecular structure of the serine proteinase inhibitor CI-2 from barley seeds. Biochemistry. 1987 Jan 13;26(1):261-9. PMID:3828302
- ↑ Ravichandran S, Sen U, Chakrabarti C, Dattagupta JK. Cryocrystallography of a Kunitz-type serine protease inhibitor: the 90 K structure of winged bean chymotrypsin inhibitor (WCI) at 2.13 A resolution. Acta Crystallogr D Biol Crystallogr. 1999 Nov;55(Pt 11):1814-21. PMID:10531477
- ↑ Radisky ES, Kwan G, Karen Lu CJ, Koshland DE Jr. Binding, proteolytic, and crystallographic analyses of mutations at the protease-inhibitor interface of the subtilisin BPN'/chymotrypsin inhibitor 2 complex. Biochemistry. 2004 Nov 2;43(43):13648-56. PMID:15504027 doi:http://dx.doi.org/10.1021/bi048797k
