This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5aqh
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues== | |
| - | + | <StructureSection load='5aqh' size='340' side='right' caption='[[5aqh]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5aqh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AQH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AQH FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZVO:5-METHYL-1,5-DIHYDRO-1,4,5,6,8-PENTAAZAACENAPHTHYLEN-3-AMINE'>ZVO</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5aqf|5aqf]], [[5aqg|5aqg]], [[5aqi|5aqi]], [[5aqj|5aqj]], [[5aqk|5aqk]], [[5aql|5aql]], [[5aqm|5aqm]], [[5aqn|5aqn]], [[5aqo|5aqo]], [[5aqp|5aqp]], [[5aqq|5aqq]], [[5aqr|5aqr]], [[5aqs|5aqs]], [[5aqt|5aqt]], [[5aqu|5aqu]], [[5aqv|5aqv]], [[5aqw|5aqw]], [[5aqx|5aqx]], [[5aqy|5aqy]], [[5aqz|5aqz]], [[5ar0|5ar0]]</td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitochondrial_protein-transporting_ATPase Mitochondrial protein-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.51 3.6.3.51] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aqh OCA], [http://pdbe.org/5aqh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aqh RCSB], [http://www.ebi.ac.uk/pdbsum/5aqh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aqh ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HSP7C_HUMAN HSP7C_HUMAN]] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.<ref>PMID:10722728</ref> [[http://www.uniprot.org/uniprot/BAG1_HUMAN BAG1_HUMAN]] Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.<ref>PMID:9305631</ref> <ref>PMID:9873016</ref> <ref>PMID:12724406</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Mitochondrial protein-transporting ATPase]] | ||
[[Category: Burke, R]] | [[Category: Burke, R]] | ||
| - | [[Category: | + | [[Category: Cheeseman, M D]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
[[Category: Collins, I]] | [[Category: Collins, I]] | ||
| - | [[Category: | + | [[Category: Dobson, S E]] |
| + | [[Category: Jeganathan, F]] | ||
| + | [[Category: Jones, A M]] | ||
[[Category: Jones, K]] | [[Category: Jones, K]] | ||
| - | [[Category: | + | [[Category: Kadi, N]] |
| - | [[Category: | + | [[Category: Lee, D]] |
| - | [[Category: | + | [[Category: Liu, M]] |
| - | [[Category: | + | [[Category: Matthews, T P]] |
| + | [[Category: McAndrew, C]] | ||
| + | [[Category: Montfort, R L.M van]] | ||
| + | [[Category: Osborne, J D]] | ||
[[Category: Richards, M]] | [[Category: Richards, M]] | ||
| - | [[Category: | + | [[Category: Rowlands, M G]] |
| - | [[Category: | + | [[Category: Westwood, I M]] |
| - | [[Category: | + | [[Category: Workman, P]] |
| - | [[Category: | + | [[Category: Yahya, N]] |
| + | [[Category: Atpase]] | ||
| + | [[Category: Bag1]] | ||
| + | [[Category: Chaperone]] | ||
| + | [[Category: Fragment]] | ||
| + | [[Category: Heat shock protein]] | ||
| + | [[Category: Hsc70]] | ||
| + | [[Category: Hsp70]] | ||
| + | [[Category: Hsp72]] | ||
Revision as of 21:20, 5 October 2016
Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues
| |||||||||||
Categories: Mitochondrial protein-transporting ATPase | Burke, R | Cheeseman, M D | Collins, I | Dobson, S E | Jeganathan, F | Jones, A M | Jones, K | Kadi, N | Lee, D | Liu, M | Matthews, T P | McAndrew, C | Montfort, R L.M van | Osborne, J D | Richards, M | Rowlands, M G | Westwood, I M | Workman, P | Yahya, N | Atpase | Bag1 | Chaperone | Fragment | Heat shock protein | Hsc70 | Hsp70 | Hsp72
