5aqh

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'''Unreleased structure'''
 
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The entry 5aqh is ON HOLD until Paper Publication
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==Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues==
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<StructureSection load='5aqh' size='340' side='right' caption='[[5aqh]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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Authors: Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., Liu, M., Richards, M., McAndrew, C., Yahya, N., Dobson, S.E., Jones, K., Workman, P., Collins, I., van Montfort, R.L.M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5aqh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AQH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AQH FirstGlance]. <br>
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Description: Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZVO:5-METHYL-1,5-DIHYDRO-1,4,5,6,8-PENTAAZAACENAPHTHYLEN-3-AMINE'>ZVO</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5aqf|5aqf]], [[5aqg|5aqg]], [[5aqi|5aqi]], [[5aqj|5aqj]], [[5aqk|5aqk]], [[5aql|5aql]], [[5aqm|5aqm]], [[5aqn|5aqn]], [[5aqo|5aqo]], [[5aqp|5aqp]], [[5aqq|5aqq]], [[5aqr|5aqr]], [[5aqs|5aqs]], [[5aqt|5aqt]], [[5aqu|5aqu]], [[5aqv|5aqv]], [[5aqw|5aqw]], [[5aqx|5aqx]], [[5aqy|5aqy]], [[5aqz|5aqz]], [[5ar0|5ar0]]</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitochondrial_protein-transporting_ATPase Mitochondrial protein-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.51 3.6.3.51] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aqh OCA], [http://pdbe.org/5aqh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aqh RCSB], [http://www.ebi.ac.uk/pdbsum/5aqh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aqh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/HSP7C_HUMAN HSP7C_HUMAN]] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.<ref>PMID:10722728</ref> [[http://www.uniprot.org/uniprot/BAG1_HUMAN BAG1_HUMAN]] Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.<ref>PMID:9305631</ref> <ref>PMID:9873016</ref> <ref>PMID:12724406</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Mitochondrial protein-transporting ATPase]]
[[Category: Burke, R]]
[[Category: Burke, R]]
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[[Category: Liu, M]]
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[[Category: Cheeseman, M D]]
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[[Category: Van Montfort, R.L.M]]
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[[Category: Lee, D]]
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[[Category: Yahya, N]]
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[[Category: Rowlands, M.G]]
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[[Category: Dobson, S.E]]
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[[Category: Collins, I]]
[[Category: Collins, I]]
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[[Category: Workman, P]]
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[[Category: Dobson, S E]]
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[[Category: Jeganathan, F]]
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[[Category: Jones, A M]]
[[Category: Jones, K]]
[[Category: Jones, K]]
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[[Category: Cheeseman, M.D]]
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[[Category: Kadi, N]]
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[[Category: Westwood, I.M]]
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[[Category: Lee, D]]
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[[Category: Mcandrew, C]]
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[[Category: Liu, M]]
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[[Category: Jones, A.M]]
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[[Category: Matthews, T P]]
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[[Category: McAndrew, C]]
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[[Category: Montfort, R L.M van]]
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[[Category: Osborne, J D]]
[[Category: Richards, M]]
[[Category: Richards, M]]
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[[Category: Kadi, N]]
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[[Category: Rowlands, M G]]
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[[Category: Jeganathan, F]]
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[[Category: Westwood, I M]]
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[[Category: Osborne, J.D]]
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[[Category: Workman, P]]
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[[Category: Matthews, T.P]]
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[[Category: Yahya, N]]
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[[Category: Atpase]]
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[[Category: Bag1]]
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[[Category: Chaperone]]
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[[Category: Fragment]]
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[[Category: Heat shock protein]]
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[[Category: Hsc70]]
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[[Category: Hsp70]]
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[[Category: Hsp72]]

Revision as of 21:20, 5 October 2016

Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues

5aqh, resolution 2.00Å

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