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5aql
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues== | |
| - | + | <StructureSection load='5aql' size='340' side='right' caption='[[5aql]], [[Resolution|resolution]] 1.69Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5aql]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AQL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AQL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5aqf|5aqf]], [[5aqg|5aqg]], [[5aqh|5aqh]], [[5aqi|5aqi]], [[5aqj|5aqj]], [[5aqk|5aqk]], [[5aqm|5aqm]], [[5aqn|5aqn]], [[5aqo|5aqo]], [[5aqp|5aqp]], [[5aqq|5aqq]], [[5aqr|5aqr]], [[5aqs|5aqs]], [[5aqt|5aqt]], [[5aqu|5aqu]], [[5aqv|5aqv]], [[5aqw|5aqw]], [[5aqx|5aqx]], [[5aqy|5aqy]], [[5aqz|5aqz]], [[5ar0|5ar0]]</td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitochondrial_protein-transporting_ATPase Mitochondrial protein-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.51 3.6.3.51] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aql OCA], [http://pdbe.org/5aql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aql RCSB], [http://www.ebi.ac.uk/pdbsum/5aql PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aql ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HSP7C_HUMAN HSP7C_HUMAN]] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.<ref>PMID:10722728</ref> [[http://www.uniprot.org/uniprot/BAG1_HUMAN BAG1_HUMAN]] Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.<ref>PMID:9305631</ref> <ref>PMID:9873016</ref> <ref>PMID:12724406</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Mitochondrial protein-transporting ATPase]] | ||
[[Category: Burke, R]] | [[Category: Burke, R]] | ||
| - | [[Category: | + | [[Category: Cheeseman, M D]] |
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[[Category: Collins, I]] | [[Category: Collins, I]] | ||
| - | [[Category: | + | [[Category: Dobson, S E]] |
| + | [[Category: Jeganathan, F]] | ||
| + | [[Category: Jones, A M]] | ||
[[Category: Jones, K]] | [[Category: Jones, K]] | ||
| - | [[Category: | + | [[Category: Kadi, N]] |
| - | [[Category: | + | [[Category: Lee, D]] |
| - | [[Category: | + | [[Category: Liu, M]] |
| - | [[Category: | + | [[Category: Matthews, T P]] |
| + | [[Category: McAndrew, C]] | ||
| + | [[Category: Montfort, R L.M van]] | ||
| + | [[Category: Osborne, J D]] | ||
[[Category: Richards, M]] | [[Category: Richards, M]] | ||
| - | [[Category: | + | [[Category: Rowlands, M G]] |
| - | [[Category: | + | [[Category: Westwood, I M]] |
| - | [[Category: | + | [[Category: Workman, P]] |
| - | [[Category: | + | [[Category: Yahya, N]] |
| + | [[Category: Atpase]] | ||
| + | [[Category: Bag1]] | ||
| + | [[Category: Chaperone]] | ||
| + | [[Category: Fragment]] | ||
| + | [[Category: Heat shock protein]] | ||
| + | [[Category: Hsc70]] | ||
| + | [[Category: Hsp70]] | ||
| + | [[Category: Hsp72]] | ||
Revision as of 21:20, 5 October 2016
Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues
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Categories: Mitochondrial protein-transporting ATPase | Burke, R | Cheeseman, M D | Collins, I | Dobson, S E | Jeganathan, F | Jones, A M | Jones, K | Kadi, N | Lee, D | Liu, M | Matthews, T P | McAndrew, C | Montfort, R L.M van | Osborne, J D | Richards, M | Rowlands, M G | Westwood, I M | Workman, P | Yahya, N | Atpase | Bag1 | Chaperone | Fragment | Heat shock protein | Hsc70 | Hsp70 | Hsp72
