5aul
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==PI3K p85 C-terminal SH2 domain/CD28-derived peptide complex== | |
| - | + | <StructureSection load='5aul' size='340' side='right' caption='[[5aul]], [[Resolution|resolution]] 1.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5aul]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AUL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr> |
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wa4|3wa4]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aul OCA], [http://pdbe.org/5aul PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aul RCSB], [http://www.ebi.ac.uk/pdbsum/5aul PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/P85A_HUMAN P85A_HUMAN]] Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.<ref>PMID:7518429</ref> <ref>PMID:17626883</ref> <ref>PMID:19805105</ref> [[http://www.uniprot.org/uniprot/CD28_HUMAN CD28_HUMAN]] Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ikura, T]] | ||
[[Category: Inaba, S]] | [[Category: Inaba, S]] | ||
| + | [[Category: Ito, N]] | ||
| + | [[Category: Morii, H]] | ||
[[Category: Numoto, N]] | [[Category: Numoto, N]] | ||
[[Category: Oda, M]] | [[Category: Oda, M]] | ||
| - | [[Category: | + | [[Category: Antigen]] |
| - | [[Category: | + | [[Category: Phosphopeptide]] |
| - | [[Category: | + | [[Category: Signaling protein]] |
Revision as of 22:53, 1 June 2016
PI3K p85 C-terminal SH2 domain/CD28-derived peptide complex
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Categories: Ikura, T | Inaba, S | Ito, N | Morii, H | Numoto, N | Oda, M | Antigen | Phosphopeptide | Signaling protein
