1aui

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[[Image:1aui.jpg|left|200px]]
[[Image:1aui.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1aui |SIZE=350|CAPTION= <scene name='initialview01'>1aui</scene>, resolution 2.1&Aring;
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The line below this paragraph, containing "STRUCTURE_1aui", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=CA1:Ca+Binding+Site'>CA1</scene>, <scene name='pdbsite=CA2:Ca+Binding+Site'>CA2</scene>, <scene name='pdbsite=CA3:Ca+Binding+Site'>CA3</scene>, <scene name='pdbsite=CA4:Ca+Binding+Site'>CA4</scene>, <scene name='pdbsite=FEB:Fe+Binding+Site'>FEB</scene> and <scene name='pdbsite=ZNB:Zn+Binding+Site'>ZNB</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1aui| PDB=1aui | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aui OCA], [http://www.ebi.ac.uk/pdbsum/1aui PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1aui RCSB]</span>
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}}
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'''HUMAN CALCINEURIN HETERODIMER'''
'''HUMAN CALCINEURIN HETERODIMER'''
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[[Category: Tempczyk, A.]]
[[Category: Tempczyk, A.]]
[[Category: Villafranca, J E.]]
[[Category: Villafranca, J E.]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: immunosuppression]]
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[[Category: Immunosuppression]]
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[[Category: phosphatase]]
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[[Category: Phosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:42:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:47:50 2008''
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Revision as of 07:42, 2 May 2008

Image:1aui.jpg

Template:STRUCTURE 1aui

HUMAN CALCINEURIN HETERODIMER


Overview

Calcineurin (CaN) is a calcium- and calmodulin-dependent protein serine/threonine phosphate which is critical for several important cellular processes, including T-cell activation. CaN is the target of the immunosuppressive drugs cyclosporin A and FK506, which inhibit CaN after forming complexes with cytoplasmic binding proteins (cyclophilin and FKBP12, respectively). We report here the crystal structures of full-length human CaN at 2.1 A resolution and of the complex of human CaN with FKBP12-FK506 at 3.5 A resolution. In the native CaN structure, an auto-inhibitory element binds at the Zn/Fe-containing active site. The metal-site geometry and active-site water structure suggest a catalytic mechanism involving nucleophilic attack on the substrate phosphate by a metal-activated water molecule. In the FKBP12-FK506-CaN complex, the auto-inhibitory element is displaced from the active site. The site of binding of FKBP12-FK506 appears to be shared by other non-competitive inhibitors of calcineurin, including a natural anchoring protein.

About this Structure

1AUI is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex., Kissinger CR, Parge HE, Knighton DR, Lewis CT, Pelletier LA, Tempczyk A, Kalish VJ, Tucker KD, Showalter RE, Moomaw EW, et al., Nature. 1995 Dec 7;378(6557):641-4. PMID:8524402 Page seeded by OCA on Fri May 2 10:42:18 2008

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OCA

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