1av5

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[[Image:1av5.gif|left|200px]]
[[Image:1av5.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1av5 |SIZE=350|CAPTION= <scene name='initialview01'>1av5</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1av5", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AVA:Active+Site+HIS+Responsible+For+Forming+The+Transient+Nu+...'>AVA</scene>, <scene name='pdbsite=AVB:Active+Site+HIS+Responsible+For+Forming+The+Transient+Nu+...'>AVB</scene>, <scene name='pdbsite=HNA:HIS+Triad+For+Which+This+Family+Was+Named'>HNA</scene> and <scene name='pdbsite=HNB:HIS+Triad+For+Which+This+Family+Was+Named'>HNB</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=AP2:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>AP2</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= HPKCI-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1av5| PDB=1av5 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1av5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1av5 OCA], [http://www.ebi.ac.uk/pdbsum/1av5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1av5 RCSB]</span>
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}}
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'''PKCI-SUBSTRATE ANALOG'''
'''PKCI-SUBSTRATE ANALOG'''
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[[Category: Klein, M G.]]
[[Category: Klein, M G.]]
[[Category: Lima, C D.]]
[[Category: Lima, C D.]]
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[[Category: histidine triad protein family]]
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[[Category: Histidine triad protein family]]
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[[Category: hit protein family]]
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[[Category: Hit protein family]]
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[[Category: nucleotidyl hydrolase]]
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[[Category: Nucleotidyl hydrolase]]
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[[Category: nucleotidyl transferase]]
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[[Category: Nucleotidyl transferase]]
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[[Category: pkci-1]]
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[[Category: Pkci-1]]
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[[Category: protein kinase inhibitor]]
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[[Category: Protein kinase inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:43:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:48:05 2008''
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Revision as of 07:43, 2 May 2008

Image:1av5.gif

Template:STRUCTURE 1av5

PKCI-SUBSTRATE ANALOG


Overview

The histidine triad (HIT) protein family is among the most ubiquitous and highly conserved in nature, but a biological activity has not yet been identified for any member of the HIT family. Fragile histidine triad protein (FHIT) and protein kinase C interacting protein (PKCI) were used in a structure-based approach to elucidate characteristics of in vivo ligands and reactions. Crystallographic structures of apo, substrate analog, pentacovalent transition-state analog, and product states of both enzymes reveal a catalytic mechanism and define substrate characteristics required for catalysis, thus unifying the HIT family as nucleotidyl hydrolases, transferases, or both. The approach described here may be useful in identifying structure-function relations between protein families identified through genomics.

About this Structure

1AV5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-based analysis of catalysis and substrate definition in the HIT protein family., Lima CD, Klein MG, Hendrickson WA, Science. 1997 Oct 10;278(5336):286-90. PMID:9323207 Page seeded by OCA on Fri May 2 10:43:48 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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